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Oxidopamine hydrobromide
🥰Excellent
Catalog No. T12352LCas No. 636-00-0
Alias 6-OHDA hydrobromide, 6-Hydroxydopamine hydrobromide
Oxidopamine hydrobromide (6-OHDA hydrobromide) is a widely used neurotoxin and an antagonist of the neurotransmitter dopamine. It selectively destroys dopaminergic neurons, promotes COX-2 activation, induces PGE2 synthesis, and stimulates the secretion of the pro-inflammatory cytokine IL-1β. It is commonly used to establish animal models of Parkinson’s disease (PD).
Oxidopamine hydrobromide
🥰Excellent
Purity: 99.88%
Catalog No. T12352LAlias 6-OHDA hydrobromide, 6-Hydroxydopamine hydrobromideCas No. 636-00-0
Oxidopamine hydrobromide (6-OHDA hydrobromide) is a widely used neurotoxin and an antagonist of the neurotransmitter dopamine. It selectively destroys dopaminergic neurons, promotes COX-2 activation, induces PGE2 synthesis, and stimulates the secretion of the pro-inflammatory cytokine IL-1β. It is commonly used to establish animal models of Parkinson’s disease (PD).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $30 | In Stock | |
| 100 mg | $48 | In Stock | |
| 500 mg | $159 | In Stock |
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Purity:99.88%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Oxidopamine hydrobromide (6-OHDA hydrobromide) is a widely used neurotoxin and an antagonist of the neurotransmitter dopamine. It selectively destroys dopaminergic neurons, promotes COX-2 activation, induces PGE2 synthesis, and stimulates the secretion of the pro-inflammatory cytokine IL-1β. It is commonly used to establish animal models of Parkinson’s disease (PD). |
| Synonyms | 6-OHDA hydrobromide, 6-Hydroxydopamine hydrobromide |
| Molecular Weight | 250.09 |
| Formula | C8H12BrNO3 |
| Cas No. | 636-00-0 |
| Smiles | Br.NCCc1cc(O)c(O)cc1O |
| Relative Density. | no data available |
| Color | Brown |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 100 mg/mL (399.86 mM), Sonication is recommended. The compound is unstable in solution, please use soon.  DMSO: 125 mg/mL (499.82 mM), Sonication is recommended. The compound is unstable in solution, please use soon. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (15.99 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
SH-SY5Y cellsProstaglandin E synthasep-p38PGE2PGE synthasePC12 cellsParkinson's diseasep38 MAPKOxidopamine hydrobromideOxidopamine HydrobromideOxidopamineneurotransmitter dopamineneurotoxicityNeuro-2a cellsMitophagyMitochondrial AutophagyLesch-Nyhan syndromeInterleukin RelatedInhibitorinhibitDopamineReceptorDopamine ReceptorDopamineCyclooxygenaseCOXCaspaseAutophagyattention-deficit hyperactivity disorderApoptosis6-OHDA Hydrobromide6-OHDA6-Hydroxydopamine Hydrobromide6-Hydroxydopamine
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