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Oxidopamine hydrobromide

🥰Excellent
Catalog No. T12352LCas No. 636-00-0
Alias 6-OHDA hydrobromide, 6-Hydroxydopamine hydrobromide

Oxidopamine hydrobromide (6-OHDA hydrobromide) is a widely used neurotoxin and an antagonist of the neurotransmitter dopamine. It selectively destroys dopaminergic neurons, promotes COX-2 activation, induces PGE2 synthesis, and stimulates the secretion of the pro-inflammatory cytokine IL-1β. It is commonly used to establish animal models of Parkinson’s disease (PD).

Oxidopamine hydrobromide
Other Forms of Oxidopamine hydrobromide:
Oxidopamine hydrochlorideT1235228094-15-7
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Oxidopamine hydrobromide

🥰Excellent
Purity: 99.88%
Catalog No. T12352LAlias 6-OHDA hydrobromide, 6-Hydroxydopamine hydrobromideCas No. 636-00-0
Oxidopamine hydrobromide (6-OHDA hydrobromide) is a widely used neurotoxin and an antagonist of the neurotransmitter dopamine. It selectively destroys dopaminergic neurons, promotes COX-2 activation, induces PGE2 synthesis, and stimulates the secretion of the pro-inflammatory cytokine IL-1β. It is commonly used to establish animal models of Parkinson’s disease (PD).
Pack SizePriceAvailabilityQuantity
50 mg$30In Stock
100 mg$48In Stock
500 mg$159In Stock
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Purity:99.88%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Oxidopamine hydrobromide (6-OHDA hydrobromide) is a widely used neurotoxin and an antagonist of the neurotransmitter dopamine. It selectively destroys dopaminergic neurons, promotes COX-2 activation, induces PGE2 synthesis, and stimulates the secretion of the pro-inflammatory cytokine IL-1β. It is commonly used to establish animal models of Parkinson’s disease (PD).
Alias6-OHDA hydrobromide, 6-Hydroxydopamine hydrobromide
Chemical Properties
Molecular Weight250.09
FormulaC8H12BrNO3
Cas No.636-00-0
SmilesBr.NCCc1cc(O)c(O)cc1O
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 100 mg/mL (399.86 mM), Sonication is recommended.
DMSO: 97 mg/mL (387.86 mM), The compound is unstable in solution, please use soon.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM3.9986 mL19.9928 mL39.9856 mL199.9280 mL
5 mM0.7997 mL3.9986 mL7.9971 mL39.9856 mL
10 mM0.3999 mL1.9993 mL3.9986 mL19.9928 mL
20 mM0.1999 mL0.9996 mL1.9993 mL9.9964 mL
50 mM0.0800 mL0.3999 mL0.7997 mL3.9986 mL
100 mM0.0400 mL0.1999 mL0.3999 mL1.9993 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

SH-SY5Y cellsProstaglandin E synthasep-p38PGE2PGE synthasePC12 cellsParkinson's diseasep38 MAPKOxidopamine hydrobromideOxidopamine HydrobromideOxidopamineneurotransmitter dopamineneurotoxicityNeuro-2a cellsMitophagyMitochondrial AutophagyLesch-Nyhan syndromeInterleukin RelatedInhibitorinhibitDopamineReceptorDopamine ReceptorDopamineCyclooxygenaseCOXCaspaseAutophagyattention-deficit hyperactivity disorderApoptosis6-OHDA Hydrobromide6-OHDA6-Hydroxydopamine Hydrobromide6-Hydroxydopamine
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