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Thiabendazole

Name: Thiabendazole
Brand: TargetMol
SKU: T0938
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0938Cas No. 148-79-8

Alias 2-(4-Thiazolyl)benzimidazole

Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.

Thiabendazole

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Purity: 99.14%

Catalog No. T0938Alias 2-(4-Thiazolyl)benzimidazoleCas No. 148-79-8

Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$29	In Stock	-
5 g	$40	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.14%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.
Targets&IC50	Proliferation (48 h, B16F10 cells):322.9 +/- 28.9 microM, Proliferation (24 h, B16F10 cells):532.4 +/- 32.6 microM, Proliferation (72 h, B16F10 cells):238.5 +/- 19.8 microM
In vitro	Thiabendazole provokes a strong DNA-damaging activity in the human lymphoblastoid cell line that constitutively expresses human CYP1A1 cDNA, but not in the parental line, indicating that CYP1A1 is chiefly implicated in carbaryl and thiabendazole genotoxicity. [1] Thiabendazole provokes a dose- and time-dependent increase in CYP1A1 (EROD activity, protein and mRNA levels) in primary culture of rat hepatocytes. [2] Thiabendazole results in the induction of 7-ethoxyresorufin O-deethylase and 7-pentoxyresorufin O-depentylase activities, CYP1A1, CYP1A2, CYP2B1 and CYP2B1/2 mRNA levels and CYP1A2 and CYP2B1/2 apoprotein levels. Thiabendazole markedly induces GSTP1 mRNA levels, but has only a small effect on GSTT1 mRNA levels. [3] Thiabendazole is rapidly transported by passive diffusion through the human intestinal cells by comparison with the protein-bound residues which are not able to cross the intestinal barrier. Thiabendazole will be firstly metabolized to 5OH-TBZ and subsequently converted to a chemically reactive metabolic intermediate binding to proteins. [4]
In vivo	Thiabendazole results in nephrosis or hydronephrosis and this organ toxicity may lead to the high dose-dependent mortality in treated mice. Thiabendazole results in hormone imbalance and this imbalance may play an important role in the changes of the reproductive or endocrine system in treated mice. [5]
Synonyms	2-(4-Thiazolyl)benzimidazole

Chemical Properties

Molecular Weight	201.25
Formula	C₁₀H₇N₃S
Cas No.	148-79-8
Smiles	N1C2=CC=CC=C2N=C1C1=CSC=N1
Relative Density.	1.406g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 1 mg/mL (4.97 mM), Sonication is recommended.

DMSO: 50 mg/mL (248.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (4.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9689 mL	24.8447 mL	49.6894 mL	248.4472 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.9938 mL	4.9689 mL	9.9379 mL	49.6894 mL
10 mM	0.4969 mL	2.4845 mL	4.9689 mL	24.8447 mL
20 mM	0.2484 mL	1.2422 mL	2.4845 mL	12.4224 mL
50 mM	0.0994 mL	0.4969 mL	0.9938 mL	4.9689 mL
100 mM	0.0497 mL	0.2484 mL	0.4969 mL	2.4845 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc