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Thiabendazole

Thiabendazole
Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.
Catalog No. T0938Cas No. 148-79-8
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Purity:99.94%
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Thiabendazole

Catalog No. T0938Cas No. 148-79-8

Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.
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Pack SizePriceAvailabilityQuantity
500 mg$41In Stock
1 g$53In Stock
1 mL x 10 mM (in DMSO)$45In Stock
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Product Introduction

Bioactivity
Description
Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.
Targets&IC50
Proliferation (24 h, B16F10 cells):532.4 +/- 32.6 microM, Proliferation (72 h, B16F10 cells):238.5 +/- 19.8 microM, Proliferation (48 h, B16F10 cells):322.9 +/- 28.9 microM
In vitro
Thiabendazole provokes a strong DNA-damaging activity in the human lymphoblastoid cell line that constitutively expresses human CYP1A1 cDNA, but not in the parental line, indicating that CYP1A1 is chiefly implicated in carbaryl and thiabendazole genotoxicity. [1] Thiabendazole provokes a dose- and time-dependent increase in CYP1A1 (EROD activity, protein and mRNA levels) in primary culture of rat hepatocytes. [2] Thiabendazole results in the induction of 7-ethoxyresorufin O-deethylase and 7-pentoxyresorufin O-depentylase activities, CYP1A1, CYP1A2, CYP2B1 and CYP2B1/2 mRNA levels and CYP1A2 and CYP2B1/2 apoprotein levels. Thiabendazole markedly induces GSTP1 mRNA levels, but has only a small effect on GSTT1 mRNA levels. [3] Thiabendazole is rapidly transported by passive diffusion through the human intestinal cells by comparison with the protein-bound residues which are not able to cross the intestinal barrier. Thiabendazole will be firstly metabolized to 5OH-TBZ and subsequently converted to a chemically reactive metabolic intermediate binding to proteins. [4]
In vivo
Thiabendazole results in nephrosis or hydronephrosis and this organ toxicity may lead to the high dose-dependent mortality in treated mice. Thiabendazole results in hormone imbalance and this imbalance may play an important role in the changes of the reproductive or endocrine system in treated mice. [5]
Alias2-(4-Thiazolyl)benzimidazole
Chemical Properties
Molecular Weight201.25
FormulaC10H7N3S
Cas No.148-79-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 1 mg/mL (4.96 mM)
DMSO: 3.85 mg/mL (19.11 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM4.9689 mL24.8447 mL49.6894 mL248.4472 mL
DMSO
1mg5mg10mg50mg
5 mM0.9938 mL4.9689 mL9.9379 mL49.6894 mL
10 mM0.4969 mL2.4845 mL4.9689 mL24.8447 mL

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