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MYF-03-69

Name: MYF-03-69
Brand: TargetMol
SKU: T62597
Rating: 4.5 (1 reviews)

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Catalog No. T62597Cas No. 2416418-11-4

Alias TEAD-IN-3, MYF03-69, MYF 03-69

MYF-03-69 (TEAD-IN-3) is a covalent and irreversible pan-TEAD inhibitor with IC₅₀ values of 385/143/558/173 nM for TEAD1/TEAD2/TEAD3/TEAD4, respectively. MYF-03-69 inhibits TEAD transcriptional activity (IC₅₀ = 56 nM), upregulates the pro-apoptotic gene BMF, and suppresses mesothelioma cancer cells with defective Hippo signaling, making it suitable for malignant pleural mesothelioma (MPM).

MYF-03-69

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Catalog No. T62597Alias TEAD-IN-3, MYF03-69, MYF 03-69Cas No. 2416418-11-4

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$893	6-8 weeks	6-8 weeks
50 mg	$1,160	6-8 weeks	6-8 weeks
100 mg	$1,860	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White to Red

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Product Introduction

Bioactivity

Description	MYF-03-69 (TEAD-IN-3) is a covalent and irreversible pan-TEAD inhibitor with IC₅₀ values of 385/143/558/173 nM for TEAD1/TEAD2/TEAD3/TEAD4, respectively. MYF-03-69 inhibits TEAD transcriptional activity (IC₅₀ = 56 nM), upregulates the pro-apoptotic gene BMF, and suppresses mesothelioma cancer cells with defective Hippo signaling, making it suitable for malignant pleural mesothelioma (MPM).
Targets&IC50	TEAD4:173 nM, TEAD1:385 nM, TEAD2:143 nM, TEAD3:558 nM
In vitro	MYF-03-69 (0–10 μM; 5 days) selectively inhibits proliferation of mesothelioma cells with defective Hippo signaling (e.g., NCI-H226, MSTO-211H) with impaired Hippo signaling, while exhibiting minimal cytotoxicity toward normal mesothelial cells or cancer cells with intact Hippo signaling [1]. MYF-03-69 (0.1–10 μM; 48 h) induced G1 phase cell cycle arrest in NCI-H226 and MSTO-211H cells [1]. MYF-03-69 (2 μM) inhibits TEAD protein palmitoylation, downregulates YAP-TEAD target genes (e.g., CTGF, CYR61, ANKRD1) in NCI-H226 cells, and upregulates the pro-apoptotic gene BMF [1].
Synonyms	TEAD-IN-3, MYF03-69, MYF 03-69

Chemical Properties

Molecular Weight	443.42
Formula	C₂₂H₂₀F₃N₅O₂
Cas No.	2416418-11-4
Smiles	O(CC1=CC=C(C(F)(F)F)C=C1)[C@H]2[C@@H](CN(C(C=C)=O)C2)N3C=C(N=N3)C=4C=CC=NC4

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (180.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2552 mL	11.2760 mL	22.5520 mL	112.7599 mL
5 mM	0.4510 mL	2.2552 mL	4.5104 mL	22.5520 mL
10 mM	0.2255 mL	1.1276 mL	2.2552 mL	11.2760 mL
20 mM	0.1128 mL	0.5638 mL	1.1276 mL	5.6380 mL
50 mM	0.0451 mL	0.2255 mL	0.4510 mL	2.2552 mL
100 mM	0.0226 mL	0.1128 mL	0.2255 mL	1.1276 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

MYF-03-69

MYF-03-69

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