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MYF-03-69
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Catalog No. T62597Cas No. 2416418-11-4
Alias TEAD-IN-3, MYF03-69, MYF 03-69
MYF-03-69 (TEAD-IN-3) is a covalent and irreversible pan-TEAD inhibitor with IC₅₀ values of 385/143/558/173 nM for TEAD1/TEAD2/TEAD3/TEAD4, respectively. MYF-03-69 inhibits TEAD transcriptional activity (IC₅₀ = 56 nM), upregulates the pro-apoptotic gene BMF, and suppresses mesothelioma cancer cells with defective Hippo signaling, making it suitable for malignant pleural mesothelioma (MPM).
MYF-03-69
😃Good
Catalog No. T62597Alias TEAD-IN-3, MYF03-69, MYF 03-69Cas No. 2416418-11-4
MYF-03-69 (TEAD-IN-3) is a covalent and irreversible pan-TEAD inhibitor with IC₅₀ values of 385/143/558/173 nM for TEAD1/TEAD2/TEAD3/TEAD4, respectively. MYF-03-69 inhibits TEAD transcriptional activity (IC₅₀ = 56 nM), upregulates the pro-apoptotic gene BMF, and suppresses mesothelioma cancer cells with defective Hippo signaling, making it suitable for malignant pleural mesothelioma (MPM).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $893 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $1,160 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $1,860 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Chemical Properties
| Description | MYF-03-69 (TEAD-IN-3) is a covalent and irreversible pan-TEAD inhibitor with IC₅₀ values of 385/143/558/173 nM for TEAD1/TEAD2/TEAD3/TEAD4, respectively. MYF-03-69 inhibits TEAD transcriptional activity (IC₅₀ = 56 nM), upregulates the pro-apoptotic gene BMF, and suppresses mesothelioma cancer cells with defective Hippo signaling, making it suitable for malignant pleural mesothelioma (MPM). |
| Targets&IC50 | TEAD4:173 nM, TEAD1:385 nM, TEAD2:143 nM, TEAD3:558 nM |
| In vitro | MYF-03-69 (0–10 μM; 5 days) selectively inhibits proliferation of mesothelioma cells with defective Hippo signaling (e.g., NCI-H226, MSTO-211H) with impaired Hippo signaling, while exhibiting minimal cytotoxicity toward normal mesothelial cells or cancer cells with intact Hippo signaling [1]. MYF-03-69 (0.1–10 μM; 48 h) induced G1 phase cell cycle arrest in NCI-H226 and MSTO-211H cells [1]. MYF-03-69 (2 μM) inhibits TEAD protein palmitoylation, downregulates YAP-TEAD target genes (e.g., CTGF, CYR61, ANKRD1) in NCI-H226 cells, and upregulates the pro-apoptotic gene BMF [1]. |
| Synonyms | TEAD-IN-3, MYF03-69, MYF 03-69 |
| Molecular Weight | 443.42 |
| Formula | C22H20F3N5O2 |
| Cas No. | 2416418-11-4 |
| Smiles | O(CC1=CC=C(C(F)(F)F)C=C1)[C@H]2[C@@H](CN(C(C=C)=O)C2)N3C=C(N=N3)C=4C=CC=NC4 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (180.42 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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