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Dexchlorpheniramine Maleate

Name: Dexchlorpheniramine Maleate
Brand: TargetMol
SKU: T0785
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0785Cas No. 2438-32-6

Alias S-(+)-Chlorpheniramine maleate salt

Dexchlorpheniramine Maleate (S-(+)-Chlorpheniramine maleate salt) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of chlorpheniramine.

Dexchlorpheniramine Maleate

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Purity: 99.58%

Catalog No. T0785Alias S-(+)-Chlorpheniramine maleate saltCas No. 2438-32-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.58%

Color:White

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COA LCMS HPLC HNMR

Product Introduction

Dexchlorpheniramine Maleate AI Summary

Dexchlorpheniramine Maleate exhibits a wide range of bioactivities across various assays and targets. It is a differential inhibitor of Plasmodium falciparum proliferation with potencies ranging from 1000.0 nM to 3981.1 nM and also inhibits Bloom's syndrome helicase (BLM) at 11220.2 nM. In addition, it inhibits RanGTP-induced Rango - Importin beta complex dissociation (11582.1 nM), human hERG channel activity (15848.9 nM), Marburg Virus binding or entry into cells (5623.4 nM), Hepatitis C Virus (HCV) (3162.3 nM), and GLP-1 Receptor Inverse Agonists (25118.9 nM). The compound effectively inhibits sodium fluorescein uptake in OATP1B1-transfected and OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 µM, with inhibition percentages of 117.74% and 103.61% respectively. It affects the transport activities of human BSEP, MRP2, MRP3, and MRP4 in Sf9 cell membrane vesicles, with IC50 values greater than 133,000.0 nM, indicating weak inhibition. In antiviral assays, Dexchlorpheniramine Maleate inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours (inhibition rate of -11.21%) and VERO-6 cells at the same concentration and exposure (inhibition rate of 0.18%). It also inhibits the SARS-CoV-2 3CL-Pro protease by 20.11% at 20 µM. The compound shows antifungal and antibacterial activities, inhibiting Candida albicans (2.45%), Cryptococcus neoformans (-7.42%), Escherichia coli (6.96%), Klebsiella pneumoniae (21.61%), Pseudomonas aeruginosa (16.81%), Acinetobacter baumannii (8.4%), and Staphylococcus aureus MRSA (5.99%). It demonstrates cell-type-specific effects on cell viability, increasing growth rates in HEK293T and human fibroblasts but not significantly impacting U2OS cells. Moreover, it affects the thermal stability of different protein domains with variable Delta TM values and is involved in GPCR beta-arrestin recruitment assays, showing both inhibitory and maximal effects on targets like GPR119, ADRB2, and others, indicating its involvement in modulating GPCR-related signaling pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dexchlorpheniramine Maleate (S-(+)-Chlorpheniramine maleate salt) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of chlorpheniramine.
Synonyms	S-(+)-Chlorpheniramine maleate salt

Chemical Properties

Molecular Weight	390.86
Formula	C₂₀H₂₃ClN₂O₄
Cas No.	2438-32-6
Smiles	CN(CC[C@@H](c1ccc(Cl)cc1)c1ncccc1)C.C(=O)(/C=C\C(=O)O)O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (115.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5585 mL	12.7923 mL	25.5846 mL	127.9230 mL
5 mM	0.5117 mL	2.5585 mL	5.1169 mL	25.5846 mL
10 mM	0.2558 mL	1.2792 mL	2.5585 mL	12.7923 mL
20 mM	0.1279 mL	0.6396 mL	1.2792 mL	6.3962 mL
50 mM	0.0512 mL	0.2558 mL	0.5117 mL	2.5585 mL
100 mM	0.0256 mL	0.1279 mL	0.2558 mL	1.2792 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc