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Legubicin

Name: Legubicin
Brand: TargetMol
SKU: T213118
Rating: 4.5 (1 reviews)

(Synonyms: Doxorubicin-LNAA-Boc) Copy Product Info

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Synonyms: Doxorubicin-LNAA-Boc

Catalog No. T213118 Copy Product Info

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Legubicin (Doxorubicin-LNAA-Boc) is a conjugate of Doxorubicin linked with a peptide connector hydrolyzable by Legumain. Upon activation by Legumain, Legubicin releases leucine-Doxorubicin, potentially minimizing damage to normal tissues. It inhibits tumor cell growth and reduces DNA binding ability in cells lacking legumain expression. In mice with CT26 tumors, Legubicin completely suppresses tumor growth, making it useful for colon cancer (CRC) research.

Legubicin

Cas No. 606967-53-7

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Legubicin (Doxorubicin-LNAA-Boc) is a conjugate of Doxorubicin linked with a peptide connector hydrolyzable by Legumain. Upon activation by Legumain, Legubicin releases leucine-Doxorubicin, potentially minimizing damage to normal tissues. It inhibits tumor cell growth and reduces DNA binding ability in cells lacking legumain expression. In mice with CT26 tumors, Legubicin completely suppresses tumor growth, making it useful for colon cancer (CRC) research.
In vivo	Legubicin (9.05 μmol/kg, intravenous injection, single dose) enhances the exposure of Doxorubicin in HT1080 tumor-bearing mice while reducing its presence in the heart and kidneys. In female SD rats and beagle dogs, Legubicin (intravenous injection, single dose, 56-day observation period) demonstrates a higher maximum tolerated dose (MTD) compared to conventional Doxorubicin and exhibits milder toxicity. When administered to SD rats, Legubicin (5-25 mg/kg, intravenous injection, once weekly, 4 weeks) induces dose-dependent toxicity. In beagle dogs, a dosage of Legubicin (3/1.5-20/10 mg/kg, intravenous injection, once weekly, 4 weeks) at 20/10 mg/kg results in an 80% mortality rate. Administered intraperitoneally, Legubicin (5-50 mg/kg, every other day, 3 doses total) completely inhibits tumor growth in Balb/C mice carrying CT26 tumors or WEHI nude mice with legumain 293, with no significant toxicity observed.
Synonyms	Doxorubicin-LNAA-Boc

Chemical Properties

Molecular Weight	1013.06
Formula	C₄₈H₆₄N₆O₁₈
Cas No.	606967-53-7
Smiles	O([C@@H]1C2=C(C(O)=C3C(=C2O)C(=O)C=4C(C3=O)=CC=CC4OC)C[C@](C(CO)=O)(O)C1)[C@H]5C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(OC(C)(C)C)=O)C)=O)C)=O)CC(N)=O)=O)CC(C)C)=O)[C@H](O)[C@H](C)O5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: Legubicin in vivo | Legubicin formula | Legubicin molecular weight