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Synonyms: Phospho-CREB (S133), p-CREB (Ser133), p-CREB (S133), CREB-1, CREB1, CREB (p-Ser133), CREB (p-S133)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 20 μL | $81 | 7-10 days | 7-10 days | |
| 100 μL | $235 | 7-10 days | 7-10 days |
| Description | Anti-Phospho-CREB (Ser133) Antibody (1Q730) is a Rabbit antibody targeting Phospho-CREB (Ser133). Anti-Phospho-CREB (Ser133) Antibody (1Q730) can be used in IHC-P,WB. |
| Synonyms | Phospho-CREB (S133), p-CREB (Ser133), p-CREB (S133), CREB-1, CREB1, CREB (p-Ser133), CREB (p-S133) |
| Ig Type | Rabbit IgG |
| Clone | 1Q730 |
| Reactivity | Human;
Predicted to React with:Phospho-CREB (Ser133), may cross with Phospho-ATF-1 (Ser63) by sequence similarity. Predicted to React with: Species predicted to react based on 100% sequence homology: Mouse, Rat, Cynomolgus, Bovine, Pig, Goat |
| Specificity | Reacts with: Human
Phospho-CREB (Ser133), may cross with Phospho-ATF-1 (Ser63) by sequence similarity. Predicted to React with: Species predicted to react based on 100% sequence homology: Mouse, Rat, Cynomolgus, Bovine, Pig, Goat |
| Application | |
| Recommended Dose | WB: 1:10000-1:200000; IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with a synthetic phosphopeptide corresponding to residues around Ser133 of human CREB. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5 |
| Research Background | CAMP responsive element binding protein 1, also known as CREB-1, plays multiple functions as a transcription factor in gene regulation. This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. CREB1 proteins are also known to be expressed in several spliced isoforms that act as transcriptional activators or repressors. The activator isoforms, possessing the functional domains for kinase induction and for interaction with other transcriptional regulators, act as transcriptional activators.The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB-1 has a complex influence on behavioural responses to drugs of abuse which varies depending on the brain region in which it is expressed. CREB-1 is important for serotonin (5-HT)-induced long-term facilitation (LTF) of the sensorimotor synapse in Aplysia. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: residues around Ser133 of human CREB. |
| Antigen Species | Human |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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