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DSM502

Name: DSM502
Brand: TargetMol
SKU: T40087
Price: 79 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40087Cas No. 2426616-55-7

DSM502 DSM502 is a dihydroorotic acid dehydrogenase (DHODH) inhibitor with antimalarial activity that inhibits Plasmodium DHODH and can be used as a lead for antimalarial compounds.

DSM502

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Purity: 99.52%

Catalog No. T40087Cas No. 2426616-55-7

DSM502 DSM502 is a dihydroorotic acid dehydrogenase (DHODH) inhibitor with antimalarial activity that inhibits Plasmodium DHODH and can be used as a lead for antimalarial compounds.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$79	-	In Stock
5 mg	$197	-	In Stock
10 mg	$317	-	In Stock
25 mg	$648	-	In Stock
50 mg	$948	-	In Stock
100 mg	$1,290	-	In Stock
1 mL x 10 mM (in DMSO)	$218	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.52%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	DSM502 DSM502 is a dihydroorotic acid dehydrogenase (DHODH) inhibitor with antimalarial activity that inhibits Plasmodium DHODH and can be used as a lead for antimalarial compounds.
Targets&IC50	DHODH (P. vivax):16 nM (IC50), DHODH (P. falciparum):20 nM (IC50)
In vitro	DSM502 has inhibitory activity against Plasmodium falciparum DHODH (Pf DHODH, IC 50 =20 nM), Plasmodium vivax DHODH (Pv DHODH, IC 50 =14 nM) and Pf 3D7 cells (EC 50 =14 nM), but has no inhibitory effect on the human enzyme [1].
In vivo	DSM502 (10 and 50 mg/kg; oral, once daily for 4 days) resulted in 97% parasite clearance in the confirmatory SCID study and 85% clearance in the GSK study; DSM502 (18.3 and 50 mg/kg; single oral dose) exhibited high oral bioavailability (>100%, >100%), apparent t 1/2 (2.6, 3.6 h) and C max (8.4, 42.3 μM) in mice; and DSM502 (2.8 mg/kg; single intravenous injection) exhibited apparent t 1/2 (2.8 h), plasma clearance (26.1 mL/min/kg) and V ss (1.2 L/kg) in mice. [1]

Chemical Properties

Molecular Weight	323.31
Formula	C₁₆H₁₆F₃N₃O
Cas No.	2426616-55-7
Smiles	Cc1c(Cc2ccc(nc2)C(F)(F)F)c[nH]c1C(=O)NC1CC1
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (463.95 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0930 mL	15.4650 mL	30.9301 mL	154.6503 mL
5 mM	0.6186 mL	3.0930 mL	6.1860 mL	30.9301 mL
10 mM	0.3093 mL	1.5465 mL	3.0930 mL	15.4650 mL
20 mM	0.1547 mL	0.7733 mL	1.5465 mL	7.7325 mL
50 mM	0.0619 mL	0.3093 mL	0.6186 mL	3.0930 mL
100 mM	0.0309 mL	0.1547 mL	0.3093 mL	1.5465 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc