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DSM502

Name: DSM502
Brand: TargetMol
SKU: T40087
Price: 79 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40087Cas No. 2426616-55-7

DSM502 DSM502 is a dihydroorotic acid dehydrogenase (DHODH) inhibitor with antimalarial activity that inhibits Plasmodium DHODH and can be used as a lead for antimalarial compounds.

DSM502

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Purity: 99.52%

Catalog No. T40087Cas No. 2426616-55-7

DSM502 DSM502 is a dihydroorotic acid dehydrogenase (DHODH) inhibitor with antimalarial activity that inhibits Plasmodium DHODH and can be used as a lead for antimalarial compounds.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$79	-	In Stock
5 mg	$197	-	In Stock
10 mg	$317	-	In Stock
25 mg	$648	-	In Stock
50 mg	$948	-	In Stock
100 mg	$1,290	-	In Stock
1 mL x 10 mM (in DMSO)	$218	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.52%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	DSM502 DSM502 is a dihydroorotic acid dehydrogenase (DHODH) inhibitor with antimalarial activity that inhibits Plasmodium DHODH and can be used as a lead for antimalarial compounds.
Targets&IC50	DHODH (P. falciparum):20 nM (IC50), DHODH (P. vivax):16 nM (IC50)
In vitro	DSM502 has inhibitory activity against Plasmodium falciparum DHODH (Pf DHODH, IC 50 =20 nM), Plasmodium vivax DHODH (Pv DHODH, IC 50 =14 nM) and Pf 3D7 cells (EC 50 =14 nM), but has no inhibitory effect on the human enzyme [1].
In vivo	DSM502 (10 and 50 mg/kg; oral, once daily for 4 days) resulted in 97% parasite clearance in the confirmatory SCID study and 85% clearance in the GSK study; DSM502 (18.3 and 50 mg/kg; single oral dose) exhibited high oral bioavailability (>100%, >100%), apparent t 1/2 (2.6, 3.6 h) and C max (8.4, 42.3 μM) in mice; and DSM502 (2.8 mg/kg; single intravenous injection) exhibited apparent t 1/2 (2.8 h), plasma clearance (26.1 mL/min/kg) and V ss (1.2 L/kg) in mice. [1]

Chemical Properties

Molecular Weight	323.31
Formula	C₁₆H₁₆F₃N₃O
Cas No.	2426616-55-7
Smiles	Cc1c(Cc2ccc(nc2)C(F)(F)F)c[nH]c1C(=O)NC1CC1
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (463.95 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0930 mL	15.4650 mL	30.9301 mL	154.6503 mL
5 mM	0.6186 mL	3.0930 mL	6.1860 mL	30.9301 mL
10 mM	0.3093 mL	1.5465 mL	3.0930 mL	15.4650 mL
20 mM	0.1547 mL	0.7733 mL	1.5465 mL	7.7325 mL
50 mM	0.0619 mL	0.3093 mL	0.6186 mL	3.0930 mL
100 mM	0.0309 mL	0.1547 mL	0.3093 mL	1.5465 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc