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4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside

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Catalog No. T37193Cas No. 37067-30-4

4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside is a fluorogenic substrate for β-hexosaminidases that releases fluorescent 4-methylumbelliferone upon enzymatic cleavage, enabling sensitive quantification of enzyme activity across pH-dependent excitation and emission ranges, and is extensively used in clinical and research assays for GM2 gangliosidoses such as Tay-Sachs disease.

4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside

4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside

😃Good
Purity: 98.92%
Catalog No. T37193Cas No. 37067-30-4
4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside is a fluorogenic substrate for β-hexosaminidases that releases fluorescent 4-methylumbelliferone upon enzymatic cleavage, enabling sensitive quantification of enzyme activity across pH-dependent excitation and emission ranges, and is extensively used in clinical and research assays for GM2 gangliosidoses such as Tay-Sachs disease.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mg$30-In Stock
100 mg$44-In Stock
500 mgPreferential-In Stock
1 mL x 10 mM (in DMSO)$35-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:98.92%
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Product Introduction

Bioactivity
Description
4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside is a fluorogenic substrate for β-hexosaminidases that releases fluorescent 4-methylumbelliferone upon enzymatic cleavage, enabling sensitive quantification of enzyme activity across pH-dependent excitation and emission ranges, and is extensively used in clinical and research assays for GM2 gangliosidoses such as Tay-Sachs disease.
In vitro
Method: Enzymatic assays using 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside as substrate were employed to screen inhibitors against the N-terminal fragment of O-GlcNAcase (nOGA).
Result: Compound 4 selectively inhibited nOGA with a Ki of 48 μM, showing 15-fold selectivity over full-length OGA and 10-fold selectivity over lysosomal hexosaminidase[1].
Chemical Properties
Molecular Weight379.36
FormulaC18H21NO8
Cas No.37067-30-4
SmilesO([C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1)C=2C=C3C(=CC2)C(C)=CC(=O)O3
Relative Density.1.4163 g/cm3 (Estimated)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (105.44 mM), Sonication is recommended.
DMF: 5 mg/mL (13.18 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (5.27 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMF/DMSO
1mg5mg10mg50mg
1 mM2.6360 mL13.1801 mL26.3602 mL131.8009 mL
5 mM0.5272 mL2.6360 mL5.2720 mL26.3602 mL
10 mM0.2636 mL1.3180 mL2.6360 mL13.1801 mL
DMSO
1mg5mg10mg50mg
20 mM0.1318 mL0.6590 mL1.3180 mL6.5900 mL
50 mM0.0527 mL0.2636 mL0.5272 mL2.6360 mL
100 mM0.0264 mL0.1318 mL0.2636 mL1.3180 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

4Methylumbelliferyl2acetamido2deoxyβDGlucopyranoside4 Methylumbelliferyl 2 acetamido 2 deoxy β D Glucopyranoside
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