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FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc)

Catalog No. TMPJ-00391
Synonyms: FGF R2b, KGFR, BFR-1, FGFR2 β, FGFR2b, FGFR2, FGFR2 beta, CD332, FGFR2IIIb

FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 85-120 KDa and the accession number is P21802-3.

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FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 86.00
50 μg 5 days $ 262.00
500 μg 5 days $ 2,150.00
1 mg 5 days $ 3,220.00
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Biological Description
Technical Params
Product Properties
Description FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 85-120 KDa and the accession number is P21802-3.
Species Human
Expression System HEK293 Cells
Tag C-hFc
Accession Number P21802-3
Synonyms FGF R2b, KGFR, BFR-1, FGFR2 β, FGFR2b, FGFR2, FGFR2 beta, CD332, FGFR2IIIb
Amino Acid Arg22-Glu378
Construction Arg22-Glu378
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 85-120 KDa (reducing condition)
Endotoxin < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

Research Background FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. A frequent splicing event involving FGF R1 and 2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform. Only the alpha isoform has been identified for FGF R3 and FGF R4. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.

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Keywords

FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc) BFR1 CD-332 FGFR 2 FGF R2b CD 332 KGFR BFR-1 FGFR2 β BFR 1 FGFR2b FGFR2 FGFR-2 FGFR2 beta CD332 FGFR2IIIb recombinant recombinant-proteins proteins protein

 

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