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CK1-IN-3

Name: CK1-IN-3
Brand: TargetMol
SKU: T60005
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60005Cas No. 349438-74-0

CK1-IN-3 is casein kinase 1 (CK1) inhibitor and can be used for research on the treatment or prevention of diseases associated with circadiantiazol rhythm, inflammation diseases.

CK1-IN-3

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Purity: 99.18%

Catalog No. T60005Cas No. 349438-74-0

CK1-IN-3 is casein kinase 1 (CK1) inhibitor and can be used for research on the treatment or prevention of diseases associated with circadiantiazol rhythm, inflammation diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$103	In Stock	In Stock
25 mg	$188	In Stock	In Stock
50 mg	$271	In Stock	In Stock
100 mg	$372	-	In Stock
200 mg	$510	-	In Stock
1 mL x 10 mM (in DMSO)	$75	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.18%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

CK1-IN-3 AI Summary

CK1-IN-3 exhibits bioactivities including the inhibition of human recombinant CK-1delta with an IC50 of 2220.0 nM using casein as a substrate after 60 minutes, as measured by the Kinase-Glo assay. It also demonstrates over 60.0% inhibition of human recombinant CK-1delta at a concentration of 10 μM under the same conditions. Additionally, CK1-IN-3 shows neuroprotective activity in Drosophila melanogaster expressing human TDP-43, resulting in a mean lifespan of 36.17 days at a concentration of 100 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CK1-IN-3 is casein kinase 1 (CK1) inhibitor and can be used for research on the treatment or prevention of diseases associated with circadiantiazol rhythm, inflammation diseases.
Targets&IC50	CK1δ:2.22 μM

Chemical Properties

Molecular Weight	328.39
Formula	C₁₇H₁₆N₂O₃S
Cas No.	349438-74-0
Smiles	N(C(CC1=C(OC)C=CC=C1)=O)C2=NC=3C(S2)=CC(OC)=CC3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (152.26 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0452 mL	15.2258 mL	30.4516 mL	152.2580 mL
5 mM	0.6090 mL	3.0452 mL	6.0903 mL	30.4516 mL
10 mM	0.3045 mL	1.5226 mL	3.0452 mL	15.2258 mL
20 mM	0.1523 mL	0.7613 mL	1.5226 mL	7.6129 mL
50 mM	0.0609 mL	0.3045 mL	0.6090 mL	3.0452 mL
100 mM	0.0305 mL	0.1523 mL	0.3045 mL	1.5226 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc