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NK01-63

Name: NK01-63
Brand: TargetMol
SKU: T60045
Rating: 4.5 (1 reviews)

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Catalog No. T60045Cas No. 2922281-15-8

Alias NK01 63

NK01-63 (Coronastat) is a potent inhibitor of the SARS-CoV-2 3CL protease.

NK01-63

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Catalog No. T60045Alias NK01 63Cas No. 2922281-15-8

NK01-63 (Coronastat) is a potent inhibitor of the SARS-CoV-2 3CL protease.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$63	Inquiry	Inquiry
2 mg	$93	Inquiry	Inquiry
5 mg	$157	Inquiry	Inquiry
10 mg	$233	Inquiry	Inquiry
25 mg	$382	Inquiry	Inquiry
50 mg	$529	Inquiry	Inquiry
100 mg	$714	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

NK01-63 AI Summary

NK01-63 exhibits bioactivity as an inhibitor of SARS-CoV-2 3CL protease, with an IC50 value of 16.0 nM. It also demonstrates antiviral activity against SARS-CoV-2 2019-nCoV/USA_WA1/2020 infected human Huh-7 cells expressing ACE2, with an EC50 value of 6.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	NK01-63 (Coronastat) is a potent inhibitor of the SARS-CoV-2 3CL protease.
Synonyms	NK01 63

Chemical Properties

Molecular Weight	575.53
Formula	C₂₂H₂₉F₃N₃NaO₈S
Cas No.	2922281-15-8
Smiles	CC(C)C[C@@H](C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(O)S(=O)(=O)[O-])NC(=O)OCC2=CC(=CC=C2)C(F)(F)F.[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (156.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (5.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7375 mL	8.6876 mL	17.3753 mL	86.8764 mL
5 mM	0.3475 mL	1.7375 mL	3.4751 mL	17.3753 mL
10 mM	0.1738 mL	0.8688 mL	1.7375 mL	8.6876 mL
20 mM	0.0869 mL	0.4344 mL	0.8688 mL	4.3438 mL
50 mM	0.0348 mL	0.1738 mL	0.3475 mL	1.7375 mL
100 mM	0.0174 mL	0.0869 mL	0.1738 mL	0.8688 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc