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Enterolactone

Name: Enterolactone
Brand: TargetMol
SKU: T41314
Price: 99 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T41314Cas No. 78473-71-9

Alias trans-α,β-Bis(3-hydroxybenzyl)butyrolactone

Enterolactone (trans-α,β-Bis(3-hydroxybenzyl)butyrolactone) is a bioactive phenolic metabolite with estrogenic properties and anti-breast cancer activity. It strongly inhibits cancer cell proliferation and migration by upregulating THBS1, synergistically suppressing epithelial ovarian cancer.

Enterolactone

🥰Excellent

Catalog No. T41314Alias trans-α,β-Bis(3-hydroxybenzyl)butyrolactoneCas No. 78473-71-9

Pack Size	Price	Availability	Quantity
500 μg	$99	In Stock

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Product Introduction

Bioactivity

Description	Enterolactone (trans-α,β-Bis(3-hydroxybenzyl)butyrolactone) is a bioactive phenolic metabolite with estrogenic properties and anti-breast cancer activity. It strongly inhibits cancer cell proliferation and migration by upregulating THBS1, synergistically suppressing epithelial ovarian cancer.
In vitro	Enterolactone (150 μM, 48h) combined with Trabe significantly inhibited the proliferation and migration of human EOC cells. [1] Enterolactone (25-75 μM,48h) blocks the growth of MDA-MB-231 breast cancer cells in the "S" phase. Enterolactone (25-75 μM,15 h) triggers apoptosis of MDA-MB-231 breast cancer cells through caspase-3 activation. [2]
In vivo	The expression of THBS1 gene in Enterolactone (l mg/kg, intraperitoneal injection) treatment group was significantly up-regulated. [1]
Synonyms	trans-α,β-Bis(3-hydroxybenzyl)butyrolactone

Chemical Properties

Molecular Weight	298.33
Formula	C₁₈H₁₈O₄
Cas No.	78473-71-9
Smiles	C([C@H]1[C@H](CC2=CC(O)=CC=C2)C(=O)OC1)C3=CC(O)=CC=C3
Relative Density.	1.298 g/cm3 at 20℃
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20.00 mg/mL (67.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3520 mL	16.7600 mL	33.5199 mL	167.5996 mL
5 mM	0.6704 mL	3.3520 mL	6.7040 mL	33.5199 mL
10 mM	0.3352 mL	1.6760 mL	3.3520 mL	16.7600 mL
20 mM	0.1676 mL	0.8380 mL	1.6760 mL	8.3800 mL
50 mM	0.0670 mL	0.3352 mL	0.6704 mL	3.3520 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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