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Quercetin

Quercetin
Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ with IC50 values of 2.4, 3.0, and 5.4 μM, respectively. Recognized as a heat shock protein inhibitor, Quercetin can significantly reduce exosome release in TII models by downregulating Hsp70 or Hsp90.
Catalog No. T2174Cas No. 117-39-5
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Purity:98.05%
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Quercetin

Catalog No. T2174Cas No. 117-39-5

Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ with IC50 values of 2.4, 3.0, and 5.4 μM, respectively. Recognized as a heat shock protein inhibitor, Quercetin can significantly reduce exosome release in TII models by downregulating Hsp70 or Hsp90.
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Pack SizePriceAvailabilityQuantity
500 mg$33.6$42In Stock
1 g$40$50In Stock
5 g$63.2$79In Stock
1 mL x 10 mM (in DMSO)$36.8$46In Stock
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Product Introduction

Bioactivity
Description
Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ with IC50 values of 2.4, 3.0, and 5.4 μM, respectively. Recognized as a heat shock protein inhibitor, Quercetin can significantly reduce exosome release in TII models by downregulating Hsp70 or Hsp90.
Targets&IC50
PI3Kγ:2.4 μM, PI3Kδ:3.0 μM
In vitro
In xenografts of human prostate cancer LNCaP and PC-3 cells, the combined administration of Quercetin (75 mg/kg) and 2-methoxyestradiol effectively inhibits tumor growth.
In vivo
Quercetin inhibits TNF-induced LDH release, reduces EC-dependent adhesion of neutrophils to bovine pulmonary artery endothelial cells (BPAEC), and also suppresses DNA synthesis and cell proliferation in these cells. As a PI3K inhibitor (IC50=2.4 - 5.4 μM), quercetin strongly inhibits PI3K and Src kinases, moderately inhibits Akt1/2, and has a slight effect on PKC, p38, and ERK1/2.
AliasSophoretin
Chemical Properties
Molecular Weight302.24
FormulaC15H10O7
Cas No.117-39-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5.7 mg/mL (18.86 mM), Working solution is recommended to be prepared and used immediately.
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 4 mg/mL (13.2 mM)
DMSO: 50 mg/mL (165.43 mM)
Solution Preparation Table
Ethanol/10% DMSO+40% PEG300+5% Tween 80+45% Saline/DMSO
1mg5mg10mg50mg
1 mM3.3086 mL16.5431 mL33.0863 mL165.4314 mL
5 mM0.6617 mL3.3086 mL6.6173 mL33.0863 mL
10 mM0.3309 mL1.6543 mL3.3086 mL16.5431 mL

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