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Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $33.6$42 | In Stock | |
1 g | $40$50 | In Stock | |
5 g | $63.2$79 | In Stock | |
1 mL x 10 mM (in DMSO) | $36.8$46 | In Stock |
Description | Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ with IC50 values of 2.4, 3.0, and 5.4 μM, respectively. Recognized as a heat shock protein inhibitor, Quercetin can significantly reduce exosome release in TII models by downregulating Hsp70 or Hsp90. |
Targets&IC50 | PI3Kγ:2.4 μM, PI3Kδ:3.0 μM |
In vitro | In xenografts of human prostate cancer LNCaP and PC-3 cells, the combined administration of Quercetin (75 mg/kg) and 2-methoxyestradiol effectively inhibits tumor growth. |
In vivo | Quercetin inhibits TNF-induced LDH release, reduces EC-dependent adhesion of neutrophils to bovine pulmonary artery endothelial cells (BPAEC), and also suppresses DNA synthesis and cell proliferation in these cells. As a PI3K inhibitor (IC50=2.4 - 5.4 μM), quercetin strongly inhibits PI3K and Src kinases, moderately inhibits Akt1/2, and has a slight effect on PKC, p38, and ERK1/2. |
Alias | Sophoretin |
Molecular Weight | 302.24 |
Formula | C15H10O7 |
Cas No. | 117-39-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5.7 mg/mL (18.86 mM), Working solution is recommended to be prepared and used immediately. H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 4 mg/mL (13.2 mM) DMSO: 50 mg/mL (165.43 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
Ethanol/10% DMSO+40% PEG300+5% Tween 80+45% Saline/DMSO
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