Shopping Cart

Your shopping cart is currently empty

Ro0711401

Name: Ro0711401
Brand: TargetMol
SKU: T9021
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T9021Cas No. 714971-87-6

Alias Ro-0711401, Ro 0711401

Ro0711401 is an agonist of mGlu1 receptor.

Ro0711401

Copy Product Info

🥰Excellent

Purity: 97.57%

Catalog No. T9021Alias Ro-0711401, Ro 0711401Cas No. 714971-87-6

Ro0711401 is an agonist of mGlu1 receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$44	In Stock	In Stock
10 mg	$73	In Stock	In Stock
25 mg	$156	In Stock	In Stock
50 mg	$249	In Stock	In Stock
100 mg	$413	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:97.57%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Ro0711401 AI Summary

Ro0711401 acts as an agonist and positive allosteric modulator at the rat and human mGlu1 receptors, stimulating an increase in intracellular and glutamate-induced calcium mobilization. It shows high oral bioavailability, moderate volume of distribution, and significant clearance in rats at 10 mg/kg, along with a short half-life and mean residence time. The compound has metabolic stability in rat microsomes, but displays high intrinsic clearance in human liver microsomes, with a notable inhibition of CYP2C9 at an IC50 value of 600.0 nM. It has a low fraction unbound in both rat and human plasma, with a low ratio of drug levels in the brain compared to plasma, indicating relatively moderate brain penetration. Despite its low clearance in human liver microsomes and rat brain, it achieves high plasma concentrations and demonstrates good brain uptake, suggesting substantial bioactivity in these tissues..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ro0711401 is an agonist of mGlu1 receptor.
Targets&IC50	mGluR1:56 nM (EC50)
Synonyms	Ro-0711401, Ro 0711401

Chemical Properties

Molecular Weight	360.29
Formula	C₁₈H₁₁F₃N₂O₃
Cas No.	714971-87-6
Smiles	FC(F)(F)c1coc(NC(=O)C2c3ccccc3Oc3ccccc23)n1
Relative Density.	1.469 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (277.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (9.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7755 mL	13.8777 mL	27.7554 mL	138.7771 mL
5 mM	0.5551 mL	2.7755 mL	5.5511 mL	27.7554 mL
10 mM	0.2776 mL	1.3878 mL	2.7755 mL	13.8777 mL
20 mM	0.1388 mL	0.6939 mL	1.3878 mL	6.9389 mL
50 mM	0.0555 mL	0.2776 mL	0.5551 mL	2.7755 mL
100 mM	0.0278 mL	0.1388 mL	0.2776 mL	1.3878 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc