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ROCK2-IN-2

🥰Excellent
Catalog No. T12747Cas No. 1995065-79-6

ROCK2-IN-2 is a selective inhibitor of ROCK2, with an IC50 of less than 1 μM.

ROCK2-IN-2

ROCK2-IN-2

🥰Excellent
Purity: 99.65%
Catalog No. T12747Cas No. 1995065-79-6
ROCK2-IN-2 is a selective inhibitor of ROCK2, with an IC50 of less than 1 μM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$48In StockIn Stock
5 mg$119In StockIn Stock
10 mg$197In StockIn Stock
25 mg$337In StockIn Stock
50 mg$496In StockIn Stock
100 mg$768In StockIn Stock
200 mg$987In StockIn Stock
1 mL x 10 mM (in DMSO)$146In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.65%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
ROCK2-IN-2 is a selective inhibitor of ROCK2, with an IC50 of less than 1 μM.
Targets&IC50
ROCK2:1 μM
In vitro
Rho-associated protein kinase (ROCK), a serine-threonine protein kinase, includes two isoforms, ROCK1 and ROCK2. ROCK2-IN-2 is involved in cellular functions such as actin organization, cell adhesion, migration, and cytokinesis. It is useful for researching treatments for fibrosis, inflammatory, autoimmune, and cardiovascular disorders [1].
Chemical Properties
Molecular Weight360.39
FormulaC18H12N6OS
Cas No.1995065-79-6
SmilesN(c1nnc(s1)-c1cccc(c1)-c1ncco1)c1ccc2[nH]ncc2c1
Relative Density.1.479 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 95 mg/mL (263.6 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 3.3 mg/mL (9.16 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7748 mL13.8739 mL27.7477 mL138.7386 mL
5 mM0.5550 mL2.7748 mL5.5495 mL27.7477 mL
10 mM0.2775 mL1.3874 mL2.7748 mL13.8739 mL
20 mM0.1387 mL0.6937 mL1.3874 mL6.9369 mL
50 mM0.0555 mL0.2775 mL0.5550 mL2.7748 mL
100 mM0.0277 mL0.1387 mL0.2775 mL1.3874 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ROKROCK2-IN-2ROCK-2-IN-2ROCK2IN2ROCK2 IN 2ROCK2ROCKRho-kinaseRho-associated protein kinaseRho-associated kinaseInhibitorinhibit
Related Tags: buy ROCK2-IN-2 | purchase ROCK2-IN-2 | ROCK2-IN-2 cost | order ROCK2-IN-2 | ROCK2-IN-2 chemical structure | ROCK2-IN-2 in vitro | ROCK2-IN-2 formula | ROCK2-IN-2 molecular weight
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