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Gisadenafil

Name: Gisadenafil
Brand: TargetMol
SKU: T15381
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15381Cas No. 334826-98-1

Alias UK-369003

Gisadenafil (UK-369003), a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM, prevents the degradation of cGMP.

Gisadenafil

🥰Excellent

Purity: 99.50%

Catalog No. T15381Alias UK-369003Cas No. 334826-98-1

Gisadenafil (UK-369003), a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM, prevents the degradation of cGMP.

Pack Size	Price	Availability
1 mg	$195	In Stock
5 mg	$437	In Stock
10 mg	$646	In Stock
25 mg	$987	In Stock
50 mg	$1,380	In Stock
100 mg	$1,860	In Stock
1 mL x 10 mM (in DMSO)	$547	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.50%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Gisadenafil (UK-369003), a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM, prevents the degradation of cGMP.
Targets&IC50	PDE5A:3.6 nM, PDE1A:9.1 μM
In vitro	In COS-7 cells, the IC50 of Gisadenafil for PDE1A is 9.1 μM, an approximately 2500-fold difference in selectivity[2].
In vivo	In male Tat-transgenic mice, Gisadenafil (2 mg/kg; i.p.) restores the dilation of small (<25 μm) arterioles following hypercapnia, although it fails to restore full dilation of larger (>25 μm) vessels. Gisadenafil largely restores the normal increase in cortical flow following hypercapnia in Tat-tg mice (17.5% above baseline)[2].
Synonyms	UK-369003

Chemical Properties

Molecular Weight	519.62
Formula	C₂₃H₃₃N₇O₅S
Cas No.	334826-98-1
Smiles	C(C)C1=C2C(=NN1CCOC)C(=O)N=C(N2)C3=C(OCC)N=CC(S(=O)(=O)N4CCN(CC)CC4)=C3
Relative Density.	1.41 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (105.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9245 mL	9.6224 mL	19.2448 mL	96.2242 mL
5 mM	0.3849 mL	1.9245 mL	3.8490 mL	19.2448 mL
10 mM	0.1924 mL	0.9622 mL	1.9245 mL	9.6224 mL
20 mM	0.0962 mL	0.4811 mL	0.9622 mL	4.8112 mL
50 mM	0.0385 mL	0.1924 mL	0.3849 mL	1.9245 mL
100 mM	0.0192 mL	0.0962 mL	0.1924 mL	0.9622 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc