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Gisadenafil

Name: Gisadenafil
Brand: TargetMol
SKU: T15381
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15381Cas No. 334826-98-1

Alias UK-369003

Gisadenafil (UK-369003), a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM, prevents the degradation of cGMP.

Gisadenafil

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Purity: 99.50%

Catalog No. T15381Alias UK-369003Cas No. 334826-98-1

Gisadenafil (UK-369003), a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM, prevents the degradation of cGMP.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$195	In Stock	In Stock
5 mg	$437	In Stock	In Stock
10 mg	$646	In Stock	In Stock
25 mg	$987	In Stock	In Stock
50 mg	$1,380	-	In Stock
100 mg	$1,860	-	In Stock
1 mL x 10 mM (in DMSO)	$547	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.50%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Gisadenafil (UK-369003), a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM, prevents the degradation of cGMP.
Targets&IC50	PDE5A:3.6 nM, PDE1A:9.1 μM
In vitro	In COS-7 cells, the IC50 of Gisadenafil for PDE1A is 9.1 μM, an approximately 2500-fold difference in selectivity[2].
In vivo	In male Tat-transgenic mice, Gisadenafil (2 mg/kg; i.p.) restores the dilation of small (<25 μm) arterioles following hypercapnia, although it fails to restore full dilation of larger (>25 μm) vessels. Gisadenafil largely restores the normal increase in cortical flow following hypercapnia in Tat-tg mice (17.5% above baseline)[2].
Synonyms	UK-369003

Chemical Properties

Molecular Weight	519.62
Formula	C₂₃H₃₃N₇O₅S
Cas No.	334826-98-1
Smiles	C(C)C1=C2C(=NN1CCOC)C(=O)N=C(N2)C3=C(OCC)N=CC(S(=O)(=O)N4CCN(CC)CC4)=C3
Relative Density.	1.41 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (105.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9245 mL	9.6224 mL	19.2448 mL	96.2242 mL
5 mM	0.3849 mL	1.9245 mL	3.8490 mL	19.2448 mL
10 mM	0.1924 mL	0.9622 mL	1.9245 mL	9.6224 mL
20 mM	0.0962 mL	0.4811 mL	0.9622 mL	4.8112 mL
50 mM	0.0385 mL	0.1924 mL	0.3849 mL	1.9245 mL
100 mM	0.0192 mL	0.0962 mL	0.1924 mL	0.9622 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc