R-(–)-Flecainide is a orally active antiarrhythmic agent that inhibits ventricular ectopic activity [1].

R-(–)-Flecainide exhibits inhibitory effects on chloroform-induced ventricular fibrillation in mice, with an ED50 of 14.5 mg/kg, administered orally in single doses ranging from 9-20 mg/kg. It also suppresses ouabain-induced arrhythmias in mongrel dogs when given intravenously at dosages of 1-3 mg/kg, demonstrating no toxicity [1]. [Animal Model: Chloroform-induced ventricular fibrillation in mice [1] Dosage: 9-20 mg/kg Administration: po, single dose Result: Prevented fibrillation.] [Animal Model: Ouabain induced ventricular tachycardia in mongrel dog [1] Dosage: 1-3 mg/kg Administration: iv, single dose Result: Inhibited arrhythmias.]