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CP-320626
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Catalog No. T31048Cas No. 186430-23-9
Alias CP320626
CP-320626 is a highly efficient human liver glycogen phosphorylase (GP) inhibitor with cholesterol-lowering activity. It inhibits cholesterol biosynthesis by directly inhibiting CYP51 and can be used in type 2 diabetes research.
CP-320626
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Purity: 98.06%
Catalog No. T31048Alias CP320626Cas No. 186430-23-9
CP-320626 is a highly efficient human liver glycogen phosphorylase (GP) inhibitor with cholesterol-lowering activity. It inhibits cholesterol biosynthesis by directly inhibiting CYP51 and can be used in type 2 diabetes research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | - | In Stock | |
| 5 mg | $722 | - | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,520 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.06%
Appearance:Solid
Color:Brown
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CP-320626 is a highly efficient human liver glycogen phosphorylase (GP) inhibitor with cholesterol-lowering activity. It inhibits cholesterol biosynthesis by directly inhibiting CYP51 and can be used in type 2 diabetes research. |
| Targets&IC50 | GP:205 nM |
| In vitro | Treatment of MIA PaCa-2 cancer cells with CP-320626 (25, 50 and 100 μM) showed significant changes in the dynamic expression of total protein and phosphoprotein. CP-320626 inhibits cholesterol production by directly inhibiting CYP51. [1] CP-320626 (50-100 μM) regulates glucose homeostasis by inhibiting glycogen phosphorylase (GP) and thereby affecting glucose production. [3] |
| In vivo | In ob/ob mice, acute treatment with CP-320626 resulted in reduced liver cholesterol production, accompanied by lanosterol accumulation, further suggesting that CYP51 inhibition is the mechanism of cholesterol reduction in these animals. [2] |
| Synonyms | CP320626 |
| Molecular Weight | 443.9 |
| Formula | C23H23ClFN3O3 |
| Cas No. | 186430-23-9 |
| Smiles | C(N[C@H](C(=O)N1CCC(O)CC1)CC2=CC=C(F)C=C2)(=O)C=3NC=4C(C3)=CC(Cl)=CC4 |
| Relative Density. | 1.401 g/cm3 (Predicted) |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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