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CP-320626
🥰Excellent
Catalog No. T31048Cas No. 186430-23-9
Alias CP320626
CP-320626 is a highly efficient human liver glycogen phosphorylase (GP) inhibitor with cholesterol-lowering activity. It inhibits cholesterol biosynthesis by directly inhibiting CYP51 and can be used in type 2 diabetes research.
CP-320626
🥰Excellent
Purity: 98.06%
Catalog No. T31048Alias CP320626Cas No. 186430-23-9
CP-320626 is a highly efficient human liver glycogen phosphorylase (GP) inhibitor with cholesterol-lowering activity. It inhibits cholesterol biosynthesis by directly inhibiting CYP51 and can be used in type 2 diabetes research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | - | In Stock | |
| 5 mg | $722 | - | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,520 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.06%
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Product Introduction
Bioactivity
Chemical Properties
| Description | CP-320626 is a highly efficient human liver glycogen phosphorylase (GP) inhibitor with cholesterol-lowering activity. It inhibits cholesterol biosynthesis by directly inhibiting CYP51 and can be used in type 2 diabetes research. |
| Targets&IC50 | GP:205 nM |
| In vitro | Treatment of MIA PaCa-2 cancer cells with CP-320626 (25, 50 and 100 μM) showed significant changes in the dynamic expression of total protein and phosphoprotein. CP-320626 inhibits cholesterol production by directly inhibiting CYP51. [1] CP-320626 (50-100 μM) regulates glucose homeostasis by inhibiting glycogen phosphorylase (GP) and thereby affecting glucose production. [3] |
| In vivo | In ob/ob mice, acute treatment with CP-320626 resulted in reduced liver cholesterol production, accompanied by lanosterol accumulation, further suggesting that CYP51 inhibition is the mechanism of cholesterol reduction in these animals. [2] |
| Synonyms | CP320626 |
| Molecular Weight | 443.9 |
| Formula | C23H23ClFN3O3 |
| Cas No. | 186430-23-9 |
| Smiles | C(N[C@H](C(=O)N1CCC(O)CC1)CC2=CC=C(F)C=C2)(=O)C=3NC=4C(C3)=CC(Cl)=CC4 |
| Relative Density. | 1.401 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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