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S1P1 Agonist III

Name: S1P1 Agonist III
Brand: TargetMol
SKU: T16833
Price: 107 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16833Cas No. 1324003-64-6

S1P1 Agonist III is an effective, orally active S1P1 receptor agonist with an EC₅₀ of 18 nM, S1P1 Agonist III has potential application in research related in inflammation and immunology.

S1P1 Agonist III

😃Good

Purity: 99.08%

Catalog No. T16833Cas No. 1324003-64-6

S1P1 Agonist III is an effective, orally active S1P1 receptor agonist with an EC₅₀ of 18 nM, S1P1 Agonist III has potential application in research related in inflammation and immunology.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$107	-	In Stock
10 mg	$178	-	In Stock
25 mg	$357	-	In Stock
50 mg	$543	-	In Stock
100 mg	$814	-	In Stock
1 mL x 10 mM (in DMSO)	$111	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.08%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	S1P1 Agonist III is an effective, orally active S1P1 receptor agonist with an EC₅₀ of 18 nM, S1P1 Agonist III has potential application in research related in inflammation and immunology.
Targets&IC50	S1P1:18 nM (EC50)
In vitro	S1P1 Agonist III demonstrates superior activity against S1P1 in Parazacco spilurus subsp. spilurus (EC50=0.035 μM, efficacy reaching 96%), with selectivity exceeding 100-fold for S1P2-5 receptor subtypes [2].
In vivo	Twenty-four hours after a single oral administration of S1P1 Agonist III (1 mg/kg) in rats, the number of circulating lymphocytes significantly decreased, with a pharmacodynamic validation value (POC) of -78% [2].

Chemical Properties

Molecular Weight	415.37
Formula	C₂₁H₁₆F₃N₃O₃
Cas No.	1324003-64-6
Smiles	O=C(NC(=O)C=1C=NC=CC1OC)NC=2C=CC(C=3C=CC=CC3)=C(C2)C(F)(F)F
Relative Density.	1.354 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 48 mg/mL (115.56 mM), Sonication is recommeded.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (6.02 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4075 mL	12.0375 mL	24.0749 mL	120.3746 mL
5 mM	0.4815 mL	2.4075 mL	4.8150 mL	24.0749 mL
10 mM	0.2407 mL	1.2037 mL	2.4075 mL	12.0375 mL
20 mM	0.1204 mL	0.6019 mL	1.2037 mL	6.0187 mL
50 mM	0.0481 mL	0.2407 mL	0.4815 mL	2.4075 mL
100 mM	0.0241 mL	0.1204 mL	0.2407 mL	1.2037 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc