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Antitumor agent-115
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Catalog No. T79580Cas No. 2759277-20-6
Antitumor agent-115 (SS-12) is a potent anti-tumor compound with an IC50 range of 0.34 μM-24.14 μM against the 4T1 mouse breast cancer cell line. It impedes the cell cycle, diminishes mitochondrial membrane potential, and triggers apoptosis, with an IC50 for cell viability spanning 8-25 μmol/L. This compound is applicable in breast cancer research [1].
Antitumor agent-115
Copy Product Info😃Good
Catalog No. T79580Cas No. 2759277-20-6
Antitumor agent-115 (SS-12) is a potent anti-tumor compound with an IC50 range of 0.34 μM-24.14 μM against the 4T1 mouse breast cancer cell line. It impedes the cell cycle, diminishes mitochondrial membrane potential, and triggers apoptosis, with an IC50 for cell viability spanning 8-25 μmol/L. This compound is applicable in breast cancer research [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Antitumor agent-115 (SS-12) is a potent anti-tumor compound with an IC50 range of 0.34 μM-24.14 μM against the 4T1 mouse breast cancer cell line. It impedes the cell cycle, diminishes mitochondrial membrane potential, and triggers apoptosis, with an IC50 for cell viability spanning 8-25 μmol/L. This compound is applicable in breast cancer research [1]. |
| In vitro | Antitumor agent-115 (SS-12) primarily induces apoptosis in 4T1 cells by causing G0/G1 phase cell cycle arrest at 1.25 μM, 10 μM, and 40 μM concentrations over 24 hours [1]. At higher concentrations (15 μM, 30 μM, and 60 μM) for the same duration, it inhibits migration and invasion of 4T1 cells. Furthermore, at 10 μM over 24 hours, it induces apoptosis via the mitochondrial pathway [1]. |
| In vivo | Antitumor agent-115 (SS-12) exhibits high bioavailability in rats at a dose of 10 mg stachydrine/kg equivalent (200 μL, oral administration) and demonstrates antitumor activity in a mouse breast cancer model at a dosage of 0.1 mL/10 g (oral administration), improving the morphological structure of the spleen in these mice [1]. |
| Molecular Weight | 347.96 |
| Formula | C19H38ClNO2 |
| Cas No. | 2759277-20-6 |
| Smiles | C(OCCCCCCCCCCCC)(=O)C1[N+](C)(C)CCC1.[Cl-] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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