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Antitumor agent-115

Catalog No. T79580 CAS 2759277-20-6

Antitumor agent-115 (SS-12) is a potent anti-tumor compound, exhibiting an IC50 range of 0.34 μM-24.14 μM against the 4T1 mouse breast cancer cell line. It impedes the cell cycle, diminishes mitochondrial membrane potential, and triggers apoptosis in these cells, with an IC50 for cell viability spanning 8-25 μmol/L. This compound is applicable in breast cancer research [1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Antitumor agent-115, CAS 2759277-20-6

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	Antitumor agent-115 (SS-12) is a potent anti-tumor compound, exhibiting an IC50 range of 0.34 μM-24.14 μM against the 4T1 mouse breast cancer cell line. It impedes the cell cycle, diminishes mitochondrial membrane potential, and triggers apoptosis in these cells, with an IC50 for cell viability spanning 8-25 μmol/L. This compound is applicable in breast cancer research [1].
In vitro	Antitumor agent-115 (SS-12) at concentrations of 1.25 μM, 10 μM, and 40 μM over a 24-hour period primarily induces apoptosis in 4T1 cells by causing a cell cycle arrest at the G0/G1 phase [1]. At increased concentrations of 15 μM, 30 μM, and 60 μM, for the same duration, it hampers the migration and invasion of 4T1 cells [1]. Additionally, at a concentration of 10 μM over 24 hours, Antitumor agent-115 induces apoptosis in these cells via the mitochondrial pathway [1].
In vivo	Antitumor agent-115 (SS-12) demonstrates high bioavailability in rats at a dose of 10 mg stachydrine/kg equivalent (200 μL, oral administration). Additionally, at a dosage of 0.1 mL/10 g (oral administration), it exhibits antitumor activity in a mouse breast cancer model and improves the morphological structure of the spleen in the model mice [1].

Molecular Weight	347.96
Formula	C19H38ClNO2
CAS No.	2759277-20-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Antitumor agent-115 2759277-20-6 Apoptosis inhibitor inhibit

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