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Anti-HVEM Antibody-APC (7C883)
🥰Excellent
Catalog No. TMAY-00633A
Anti-HVEM Antibody-APC (7C883) is a APC-conjugated Mouse antibody targeting HVEM. Anti-HVEM Antibody-APC (7C883) can be used in FCM.
Anti-HVEM Antibody-APC (7C883)
Anti-HVEM Antibody-APC (7C883)
🥰Excellent
Catalog No. TMAY-00633A
Anti-HVEM Antibody-APC (7C883) is a APC-conjugated Mouse antibody targeting HVEM. Anti-HVEM Antibody-APC (7C883) can be used in FCM.
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Product Introduction
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Chemical Properties
| Description | Anti-HVEM Antibody-APC (7C883) is a APC-conjugated Mouse antibody targeting HVEM. Anti-HVEM Antibody-APC (7C883) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 7C883 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human HVEM(CD270) expression on human whole blood lymphocytes. Cells were stained with APC-conjugated anti-Human HVEM(CD270). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human HVEM/TNFRSF14/CD270 (rh HVEM/TNFRSF14/CD270; TMPY-01750; NP_003811.2; Met1-Val202) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor superfamily. It is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling. However, recent studies have revealed that HVEM is also involved in the unique inhibitory signaling pathway for T cells through activating tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) in B and T lymphocyte attenuator (BTLA). HVEM provides a stimulatory signal following engagement with LIGHT (TNFSF14) on T cells. In contrast, it can also provide an inhibitory signal to T cells when it binds the B and T lymphocyte attenuator (BTLA), a ligand member of the Immunoglobulin (Ig) superfamily. Thus, HVEM may be viewed as a molecular switch, capable of facilitating both stimulatory and inhibitory cosignaling in T cells. Substantial evidence from both human disease and from experimental mouse models has indicated that dysregulation of the LIGHT-HVEM-BTLA cosignaling pathway can cause inflammation in the lung and in mucosal tissues.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| Conjucates | APC |
| Others Formats | Unconjugated/PE |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Human HVEM/TNFRSF14/CD270 Protein (TMPY-01750) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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