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Bixin
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Catalog No. T10554Cas No. 6983-79-5
Bixin is an orally active carotenoid that modulates TLR4/NF-κB, Nrf2, and ROS to mitigate high-fat diet-induced cardiac injury in mice and induces apoptosis in A549, HeLa, and MCF-7 cells.
Bixin
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Purity: 99.84%
Catalog No. T10554Cas No. 6983-79-5
Bixin is an orally active carotenoid that modulates TLR4/NF-κB, Nrf2, and ROS to mitigate high-fat diet-induced cardiac injury in mice and induces apoptosis in A549, HeLa, and MCF-7 cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $77 | - | In Stock | |
| 5 mg | $197 | - | In Stock | |
| 10 mg | $313 | - | In Stock | |
| 25 mg | $528 | - | In Stock | |
| 50 mg | $752 | - | In Stock | |
| 100 mg | $987 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $169 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.84%
Appearance:Solid
Color:Brown
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Bixin is an orally active carotenoid that modulates TLR4/NF-κB, Nrf2, and ROS to mitigate high-fat diet-induced cardiac injury in mice and induces apoptosis in A549, HeLa, and MCF-7 cells. |
| In vitro | Bixin (20-80 μM, 24 hours) not only ameliorated LPS-induced cellular fibrosis in H9C2 cells without cytotoxicity, but also alleviated inflammatory responses by inactivating the TLR4/NF-κB pathway and suppressed LPS-mediated ROS generation through activating the Nrf2 pathway [1]. Bixin (0-500 μM, 48 hours) exhibited anti-proliferative effects on three tumor cell lines: Human lung cancer (A549), cervical cancer (HeLa), and breast cancer (MCF-7) [2]. |
| In vivo | Bixin (50-200 mg/kg, orally administered once daily for 14 weeks) alleviates systemic inflammatory responses in a high-fat diet-induced mouse model by inhibiting the activation of the TLR4/NF-κB signaling pathway and reducing pro-inflammatory cytokine secretion. It also decreases ROS production through activation of the Nrf2 pathway while effectively ameliorating systemic metabolic disorder in mice [1]. |
| Molecular Weight | 394.50 |
| Formula | C25H30O4 |
| Cas No. | 6983-79-5 |
| Smiles | COC(=O)\C=C\C(\C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)/C=C/C(O)=O |
| Relative Density. | 1.31g/cm3 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5.50 mg/mL (13.94 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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