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Anti-Phospho-PDGFRB (Y740) Antibody (1I961) is a Rabbit antibody targeting Phospho-PDGFRB (Y740). Anti-Phospho-PDGFRB (Y740) Antibody (1I961) can be used in WB,ICC/IF.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $298 | 7-10 days | |
100 μL | $496 | 7-10 days |
Description | Anti-Phospho-PDGFRB (Y740) Antibody (1I961) is a Rabbit antibody targeting Phospho-PDGFRB (Y740). Anti-Phospho-PDGFRB (Y740) Antibody (1I961) can be used in WB,ICC/IF. |
Ig Type | IgG |
Reactivity | Mouse,Rat |
Application | |
Recommended Dose | WB: 1:1000; ICC/IF: 1:50-200 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | Hybridoma Monoclonal Antibody |
Purification | ProA affinity purified |
Appearance | Liquid |
Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
Research Background | Platelet Derived Growth Factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PDGF-AA, PDGF-AB, and PDGF-BB. These three isoforms bind with different affinities to two receptor types, a and b, which are endowed with protein tyrosine kinase domains and undergo either homo- or heterodimerization as a consequence of ligand binding. Ligand stimulation of PDGFR-b leads to autophosphorylation at Tyr-857, which is the major autophosphorylation site, and Tyr-751, which is the major in vitro phosphorylation site. Autophosphorylation of Tyr-751, which lies in the kinase insert region, is required for binding of phosphatidylinositol-3 kinase to the receptor. These auto-phosphorylation events largely contribute to signal transduction through the PDGF receptor. |
Conjucates | Unconjugated |
Others Formats | Phospho |
Immunogen | A synthesized phosphopeptide: human PDGF Receptor beta around the phosphorylation site of Tyr740 |
Antigen Species | human |
Uniprot ID |
Molecular Weight | Theoretical: 190 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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