IL-36 alpha/IL-1F6 Protein, Mouse, Recombinant

Name: IL-36 alpha/IL-1F6 Protein, Mouse, Recombinant
Brand: TargetMol
SKU: TMPY-01956
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: interleukin 36, α, interleukin 36, alpha, IL36 α/IL-1F6, IL-1F6, IL1F6, IL1(ε), IL1(EPSILON), FIL1E, FIL1(ε), FIL1(EPSILON), FIL1) Copy Product Info

Synonyms: interleukin 36, α, interleukin 36, alpha, IL36 α/IL-1F6, IL-1F6, IL1F6, IL1(ε), IL1(EPSILON), FIL1E, FIL1(ε), FIL1(EPSILON), FIL1

Catalog No. TMPY-01956 Copy Product Info

Purity: 96.4%

IL-36 alpha/IL-1F6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is Q9JLA2-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$88	-	In Stock
10 µg	$142	-	In Stock
20 µg	$233	-	In Stock
50 µg	$462	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:96.4%

Appearance:Lyophilized powder

Color:White

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COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	IL-36 alpha/IL-1F6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is Q9JLA2-1.
Species	Mouse
Expression System	E. coli
Tag	Tag Free
Accession Number	Q9JLA2-1
Construction	A DNA sequence encoding the mouse IL1F6 (Q9JLA2-1) (Met 1-His 160) was expressed and purified. Predicted N terminal: Met 1
Protein Purity	> 97 % as determined by SDS-PAGE
Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	interleukin 36, α, interleukin 36, alpha, IL36 α/IL-1F6, IL-1F6, IL1F6, IL1(ε), IL1(EPSILON), FIL1E, FIL1(ε), FIL1(EPSILON), FIL1
Research Background	Interleukin-1 family member 6 (IL-1F6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine that plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. It has been reported that IL-1F6 and IL-1F8, in addition to IL-1F9, activate the pathway leading to NF-kappaB in an IL-1Rrp2-dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines. Activation of the pathway leading to NF-kappaB by IL-1F6 and IL-1F8 follows a similar time course to activation by IL-1beta, suggesting that signaling by the novel family members occurs through a direct mechanism. In a mammary epithelial cell line, NCI/ADR-RES, which naturally expresses IL-1Rrp2, all three cytokines signal without further receptor transfection. IL-1Rrp2 antibodies block activation of the pathway leading to NF-kappaB by IL-1F6, IL-1F8, and IL-1F9 in both Jurkat and NCI/ADR-RES cells. Thus IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP.

Chemical Properties

Molecular Weight

18 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.