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5-HT2 antagonist 1

Name: 5-HT2 antagonist 1
Brand: TargetMol
SKU: T12597
Price: 714 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12597 Copy Product Info

Purity: 99.76%

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5-HT2 antagonist 1 is a small molecule antagonist functioning as a 5-HT2B receptor antagonist (IC50 = 33.4 nM), with oral bioactivity and weak inhibition of α1 receptors, employed in research on hepatocellular carcinoma and related diseases.

Cas No. 191592-09-3

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Pack Size	Price	USA Stock	Global Stock
1 mg	$714	In Stock	In Stock
5 mg	$1,430	In Stock	In Stock
10 mg	$1,930	In Stock	In Stock
25 mg	$2,870	In Stock	In Stock
50 mg	$3,870	In Stock	In Stock
100 mg	$5,230	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$1,690	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.76%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	5-HT2 antagonist 1 is a small molecule antagonist functioning as a 5-HT2B receptor antagonist (IC50 = 33.4 nM), with oral bioactivity and weak inhibition of α1 receptors, employed in research on hepatocellular carcinoma and related diseases.
In vitro	Methods: In guinea pig mesenteric arteries, 10 μM serotonin-induced contractions were established, and 10 nM, 100 nM, and 1000 nM of 5-HT2 antagonist 1 were administered to observe the inhibitory effects; in guinea pig aorta, 10 μM norepinephrine-induced contractions were established, and 10 nM and 100 nM of 5-HT2 antagonist 1 were administered to observe the inhibitory effects. Results: 5-HT2 antagonist 1 produced inhibitory effects of 45%, 88%, and 93% at concentrations of 10 nM, 100 nM, and 1000 nM, respectively; inhibitions of 1% and 10% were observed at concentrations of 10 nM and 100 nM, respectively. [1]
In vivo	Methods: To investigate the effect of 5-HT2 antagonist 1 (compound 15) on visceral hypersensitivity in irritable bowel syndrome (IBS) rats, 5-HT2B antagonist-1 (compound 15) at 30 mg/kg was administered via oral gavage to IBS rats. Results: 5-HT2B antagonist-1 significantly reduced visceral hypersensitivity in IBS rats. [2]

Chemical Properties

Molecular Weight	400.49
Formula	C₂₂H₂₉FN₄O₂
Cas No.	191592-09-3
Smiles	CN1C2=C(C(=O)N(CCCN3CCN(CC3)C4=CC=C(F)C=C4)CCC2O)C=C1
Relative Density.	1.28 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 85 mg/mL (212.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4969 mL	12.4847 mL	24.9694 mL	124.8471 mL
5 mM	0.4994 mL	2.4969 mL	4.9939 mL	24.9694 mL
10 mM	0.2497 mL	1.2485 mL	2.4969 mL	12.4847 mL
20 mM	0.1248 mL	0.6242 mL	1.2485 mL	6.2424 mL
50 mM	0.0499 mL	0.2497 mL	0.4994 mL	2.4969 mL
100 mM	0.0250 mL	0.1248 mL	0.2497 mL	1.2485 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

5HTReceptor5-HT-2 antagonist 15-HT2 antagonist 15HT2 antagonist 15-HT25HT Receptor5 HT2 antagonist 1

Related Tags: 5-HT2 antagonist 1 chemical structure | 5-HT2 antagonist 1 in vivo | 5-HT2 antagonist 1 in vitro | 5-HT2 antagonist 1 formula | 5-HT2 antagonist 1 molecular weight