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CGRP antagonist 1

Name: CGRP antagonist 1
Brand: TargetMol
SKU: T13453
Price: 342 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13453Cas No. 1123757-49-2

CGRP antagonist 1 is a potent CGRP receptor antagonist with Ki values of 35 nM and IC50 values of 57 nM, respectively.CGRP antagonist 1 can be used for the study of cardiovascular and neurovascular diseases.

CGRP antagonist 1

🥰Excellent

Purity: 99.68%

Catalog No. T13453Cas No. 1123757-49-2

Pack Size	Price	Availability
1 mg	$342	In Stock
5 mg	$828	In Stock
10 mg	$1,150	In Stock
25 mg	$1,680	In Stock
50 mg	$2,290	In Stock
100 mg	$2,970	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.68%

ee:100%

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COA CSFC HNMR LCMS ORP

Product Introduction

Bioactivity

Description	CGRP antagonist 1 is a potent CGRP receptor antagonist with Ki values of 35 nM and IC50 values of 57 nM, respectively.CGRP antagonist 1 can be used for the study of cardiovascular and neurovascular diseases.
Targets&IC50	CGRP receptor:35 nM（Ki）, CGRP receptor:57 nM

Chemical Properties

Molecular Weight	494.54
Formula	C₂₉H₂₆N₄O₄
Cas No.	1123757-49-2
Smiles	O=C1[C@]2(C=3C(N1)=NC=CC3)CC=4C(C2)=CC=C(NC(CN5C=6C(C7(C5=O)CCOCC7)=CC=CC6)=O)C4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (121.32 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0221 mL	10.1104 mL	20.2208 mL	101.1041 mL
5 mM	0.4044 mL	2.0221 mL	4.0442 mL	20.2208 mL
10 mM	0.2022 mL	1.0110 mL	2.0221 mL	10.1104 mL
20 mM	0.1011 mL	0.5055 mL	1.0110 mL	5.0552 mL
50 mM	0.0404 mL	0.2022 mL	0.4044 mL	2.0221 mL
100 mM	0.0202 mL	0.1011 mL	0.2022 mL	1.0110 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc