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ATF4-IN-2

Name: ATF4-IN-2
Brand: TargetMol
SKU: T85740
Price: 133 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T85740Cas No. 2991057-60-2

ATF4-IN-2 (Compound 29) is an ATF4 inhibitor (IC50=47.71 nM) for neurodegenerative disease research.

ATF4-IN-2

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Purity: 98.80%

Catalog No. T85740Cas No. 2991057-60-2

ATF4-IN-2 (Compound 29) is an ATF4 inhibitor (IC50=47.71 nM) for neurodegenerative disease research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$133	-	In Stock
5 mg	Preferential	-	In Stock
10 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.80%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ATF4-IN-2 (Compound 29) is an ATF4 inhibitor (IC50=47.71 nM) for neurodegenerative disease research.
Targets&IC50	ATF4:47.71 nM

Chemical Properties

Molecular Weight	558.81
Formula	C₂₄H₂₁BrClN₅O₄
Cas No.	2991057-60-2
Smiles	O=C(NCC1CCN(NC(=O)C=2OC=3C=CC(Cl)=CC3C2)CC1)C4=NN=C(O4)C=5C=CC(Br)=CC5
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (143.16 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7895 mL	8.9476 mL	17.8952 mL	89.4759 mL
5 mM	0.3579 mL	1.7895 mL	3.5790 mL	17.8952 mL
10 mM	0.1790 mL	0.8948 mL	1.7895 mL	8.9476 mL
20 mM	0.0895 mL	0.4474 mL	0.8948 mL	4.4738 mL
50 mM	0.0358 mL	0.1790 mL	0.3579 mL	1.7895 mL
100 mM	0.0179 mL	0.0895 mL	0.1790 mL	0.8948 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc