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SM360320
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Catalog No. T19675Cas No. 226907-52-4
Alias SM-360320, SM 360320, CL-087, CL087, CL 087, 1V136
SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for research on acting as an immunological adjuv
SM360320
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Purity: 99.13%
Catalog No. T19675Alias SM-360320, SM 360320, CL-087, CL087, CL 087, 1V136Cas No. 226907-52-4
SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for research on acting as an immunological adjuv
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $118 | In Stock | In Stock | |
| 5 mg | $256 | In Stock | In Stock | |
| 10 mg | $383 | In Stock | In Stock | |
| 25 mg | $592 | In Stock | In Stock | |
| 50 mg | $822 | In Stock | In Stock | |
| 100 mg | $1,090 | In Stock | In Stock | |
| 500 mg | $2,210 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $283 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.13%
Appearance:Solid
Color:Yellow
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Product Introduction
SM360320 AI Summary
SM360320 exhibits binding affinity and antagonist activity towards multiple human adenosine receptors, particularly the A2A receptor with a Ki value of 6.6 nM, and the A1 receptor with Ki values of 71.8 nM and 79.2 nM as measured in different assays. It also demonstrates a significant selectivity towards the A1 and A2b receptors and does not show substantial inhibition of the adenosine A3 receptor (Ki > 10000 nM) or various other receptor types including Beta-2 adrenergic, GABA, Dopamine, AMPA, and NMDA at a concentration of 1 μM. Additionally, SM360320 exhibits minor inhibition of the ADO transporter by 24%..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for research on acting as an immunological adjuv |
| Synonyms | SM-360320, SM 360320, CL-087, CL087, CL 087, 1V136 |
| Molecular Weight | 315.33 |
| Formula | C15H17N5O3 |
| Cas No. | 226907-52-4 |
| Smiles | COCCOc1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1 |
| Relative Density. | 1.356 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 120 mg/mL (380.55 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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