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TH-Z145

Name: TH-Z145
Brand: TargetMol
SKU: T73450
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T73450Cas No. 2260887-57-6

TH-Z145 is a potent FPPS inhibitor for the study of myeloma and lung cancer.

TH-Z145

😃Good

Purity: 98.29%

Catalog No. T73450Cas No. 2260887-57-6

TH-Z145 is a potent FPPS inhibitor for the study of myeloma and lung cancer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	-	In Stock
5 mg	$105	-	In Stock
10 mg	$172	-	In Stock
25 mg	$355	-	In Stock
50 mg	$572	-	In Stock
100 mg	$913	-	In Stock
1 mL x 10 mM (in DMSO)	$116	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.29%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	TH-Z145 is a potent FPPS inhibitor for the study of myeloma and lung cancer.
In vivo	In a pathogenic influenza model, TH-Z145 (20 μg, i.p.) demonstrates strong prophylactic effects[1].

Chemical Properties

Molecular Weight	394.34
Formula	C₁₆H₂₈O₇P₂
Cas No.	2260887-57-6
Smiles	C(C(P(=O)(O)O)P(=O)(O)O)C1=CC(OCCCCCCCC)=CC=C1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (202.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5359 mL	12.6794 mL	25.3588 mL	126.7941 mL
5 mM	0.5072 mL	2.5359 mL	5.0718 mL	25.3588 mL
10 mM	0.2536 mL	1.2679 mL	2.5359 mL	12.6794 mL
20 mM	0.1268 mL	0.6340 mL	1.2679 mL	6.3397 mL
50 mM	0.0507 mL	0.2536 mL	0.5072 mL	2.5359 mL
100 mM	0.0254 mL	0.1268 mL	0.2536 mL	1.2679 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc