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Telotristat ethyl

Name: Telotristat ethyl
Brand: TargetMol
SKU: T11897
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11897Cas No. 1033805-22-9

Alias LX1606

Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

Telotristat ethyl

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Purity: 99.89%

Catalog No. T11897Alias LX1606Cas No. 1033805-22-9

Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
5 mg	$77	In Stock	In Stock
10 mg	$123	In Stock	In Stock
25 mg	$232	In Stock	In Stock
50 mg	$376	In Stock	In Stock
100 mg	$566	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Color:White to Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
In vivo	Telotristat ethyl, at a dosage of 200 mg/kg administered orally once daily, has been shown to protect against inflammatory bowel disease (IBD) in mice, as evidenced by histopathology evaluations[1] and by alleviating the severity of colitis induced by trinitrobenzene sulfonic acid (TNBS)[2]. At various dosages (15, 50, 150, 300 mg/kg), Telotristat ethyl effectively reduces serotonin (5-HT) levels in the jejunum, though it does not affect serotonin levels in the brain or impact the enteric neuronal serotonin nor constitutive gastrointestinal motility at a 200 mg/kg dosage. Additionally, it prevents the TNBS-induced increase in blood neutrophil counts, highlighting its significant protective role in a mouse model of IBD, without altering serotonin content within the brain, even at differing concentrations (15, 50, 150, 300 mg/kg, administered orally once daily).
Synonyms	LX1606

Chemical Properties

Molecular Weight	574.98
Formula	C₂₇H₂₆ClF₃N₆O₃
Cas No.	1033805-22-9
Smiles	CCOC(=O)[C@@H](N)Cc1ccc(cc1)-c1cc(O[C@H](c2ccc(Cl)cc2-n2ccc(C)n2)C(F)(F)F)nc(N)n1
Relative Density.	1.42

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 115 mg/mL (200.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7392 mL	8.6960 mL	17.3919 mL	86.9595 mL
5 mM	0.3478 mL	1.7392 mL	3.4784 mL	17.3919 mL
10 mM	0.1739 mL	0.8696 mL	1.7392 mL	8.6960 mL
20 mM	0.0870 mL	0.4348 mL	0.8696 mL	4.3480 mL
50 mM	0.0348 mL	0.1739 mL	0.3478 mL	1.7392 mL
100 mM	0.0174 mL	0.0870 mL	0.1739 mL	0.8696 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc