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(R)-GNE-140

🥰Excellent
Catalog No. T4295Cas No. 2003234-63-5
Alias GNE-140

(R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer.

(R)-GNE-140
Other Forms of (R)-GNE-140:

(R)-GNE-140

🥰Excellent
Purity: 98.91%
Catalog No. T4295Alias GNE-140Cas No. 2003234-63-5
(R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$67In StockIn Stock
5 mg$163In StockIn Stock
10 mg$229In StockIn Stock
25 mg$378In StockIn Stock
50 mg$513In StockIn Stock
100 mg$695In StockIn Stock
1 mL x 10 mM (in DMSO)$178In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.91%
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Product Introduction

Bioactivity
Description
(R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer.
Targets&IC50
LDHA:3 nM, LDHB:5 nM
In vitro
(R)-GNE-140 (5 μM) inhibits proliferation in 37 of 347 cancer cell lines. (R)-GNE-140 has an inhibitory effect on two chondrosarcomas (bone) cancer cell lines that harbor IDH1 mutations (IC50: 0.8 mΜ).
In vivo
(R)-GNE-140 demonstrates high bioavailability in mice at 5 mg/kg and achieves greater exposure at oral doses of 50-200 mg/kg.
SynonymsGNE-140
Chemical Properties
Molecular Weight499.04
FormulaC25H23ClN2O3S2
Cas No.2003234-63-5
SmilesOC1=C(Sc2ccccc2Cl)C(=O)N[C@@](C1)(c1ccsc1)c1ccc(cc1)N1CCOCC1
Relative Density.1.46 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 9.38 mg/mL (18.79 mM), Sonication is recommended.
DMF: 25mg/mL (50.09 mM), Sonication is recommended.
H2O: < 0.1 mg/mL (insoluble)
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO/DMF
1mg5mg10mg50mg
1 mM2.0038 mL10.0192 mL20.0385 mL100.1924 mL
5 mM0.4008 mL2.0038 mL4.0077 mL20.0385 mL
10 mM0.2004 mL1.0019 mL2.0038 mL10.0192 mL
DMF
1mg5mg10mg50mg
20 mM0.1002 mL0.5010 mL1.0019 mL5.0096 mL
50 mM0.0401 mL0.2004 mL0.4008 mL2.0038 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

LDHLactate DehydrogenaseInhibitorinhibitGNE140GNE 140(R)GNE140(R) GNE 140
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