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β-Aminopropionitrile hydrochloride
🥰Excellent
Catalog No. T72103Cas No. 646-03-7
Alias BAPN hydrochloride
β-Aminopropionitrile hydrochloride is a selective, orally available, irreversible inhibitor of lysyl oxidase (LOX) that reduces metastatic seeding potential in MDA-MB-231 breast cancer cells.
β-Aminopropionitrile hydrochloride
🥰Excellent
Purity: 99.32%
Catalog No. T72103Alias BAPN hydrochlorideCas No. 646-03-7
β-Aminopropionitrile hydrochloride is a selective, orally available, irreversible inhibitor of lysyl oxidase (LOX) that reduces metastatic seeding potential in MDA-MB-231 breast cancer cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | - | In Stock | |
| 5 mg | $722 | - | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,520 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 100 mg | $2,760 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.32%
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Product Introduction
Bioactivity
Chemical Properties
| Description | β-Aminopropionitrile hydrochloride is a selective, orally available, irreversible inhibitor of lysyl oxidase (LOX) that reduces metastatic seeding potential in MDA-MB-231 breast cancer cells. |
| In vitro | In an in vitro model of insulin resistance, β-Aminopropionitrile hydrochloride can restore the expression of GLUT4 and adiponectin to normal levels and improve Vitis vinifera sugar uptake [1]. β-Aminopropionitrile hydrochloride (500 μM, 72 hours) can block hypoxia-induced epithelial-mesenchymal transition (EMT) morphological changes and marker protein alterations in cervical squamous cell carcinoma cells, while also inhibiting their invasion and migration capabilities (in vitro experiment) [2]. |
| In vivo | β-Aminopropionitrile hydrochloride, at a dose of 100 mg/kg/day administered orally for 6 weeks, reduced weight gain and improved metabolic profiles in diet-induced obese rats [1]. β-Aminopropionitrile hydrochloride, at a dose of 1 g/kg/day administered orally for 4 weeks, induced thoracic aortic dissection in C57BL/6 mice [3]. |
| Synonyms | BAPN hydrochloride |
| Molecular Weight | 106.55 |
| Formula | C3H7ClN2 |
| Cas No. | 646-03-7 |
| Smiles | Cl.N#CCCN |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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