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dCeMM4

Name: dCeMM4
Brand: TargetMol
SKU: T61057
Rating: 4.5 (1 reviews)

Catalog No. T61057 Copy Product Info

Purity: 99.93%

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dCeMM4 is a molecular glue degrader targeting the RBM39 protein. It recruits RBM39 to the E3 ubiquitin ligase complex for degradation, disrupting splicesome function to inhibit tumor growth in TPD research.

dCeMM4

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Catalog No. T61057

Cas No. 1281683-44-0

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Purity:99.93%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	dCeMM4 is a molecular glue degrader targeting the RBM39 protein. It recruits RBM39 to the E3 ubiquitin ligase complex for degradation, disrupting splicesome function to inhibit tumor growth in TPD research.
In vitro	In vitro assays show that dCeMM4 remodels CRL4B to recruit CDK12, inducing degradation of Cyclin K [1].

Chemical Properties

Molecular Weight	337.42
Formula	C₁₄H₁₅N₃O₃S₂
Cas No.	1281683-44-0
Smiles	O=C(C=1OC(=CC1)C)N2CSCC2C(=O)NC3=NC=C(S3)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 2.6 mg/mL (7.71 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9637 mL	14.8183 mL	29.6367 mL	148.1833 mL
5 mM	0.5927 mL	2.9637 mL	5.9273 mL	29.6367 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc