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R 59-022
🥰Excellent
Catalog No. T16709Cas No. 93076-89-2
Alias DKGI-I, Diacylglycerol kinase inhibitor I
R 59-022 (DKGI-I) is a diacylglycerol kinase (DGK) inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells. R 59-022 activates protein kinase C (PKC), inhibits intestinal smooth muscle contractility, and enhances O2- production induced by 1-oleoyl-2-acetylglycerol.
R 59-022
🥰Excellent
Purity: 98.55%
Catalog No. T16709Alias DKGI-I, Diacylglycerol kinase inhibitor ICas No. 93076-89-2
R 59-022 (DKGI-I) is a diacylglycerol kinase (DGK) inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells. R 59-022 activates protein kinase C (PKC), inhibits intestinal smooth muscle contractility, and enhances O2- production induced by 1-oleoyl-2-acetylglycerol.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $32 | In Stock | |
| 5 mg | $72 | In Stock | |
| 10 mg | $128 | In Stock | |
| 25 mg | $298 | In Stock | |
| 50 mg | $497 | In Stock | |
| 100 mg | $815 | In Stock | |
| 200 mg | $1,080 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $73 | In Stock |
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Purity:98.55%
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Product Introduction
Bioactivity
Chemical Properties
| Description | R 59-022 (DKGI-I) is a diacylglycerol kinase (DGK) inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells. R 59-022 activates protein kinase C (PKC), inhibits intestinal smooth muscle contractility, and enhances O2- production induced by 1-oleoyl-2-acetylglycerol. |
| Targets&IC50 | EBOV GP:~2 µM, DGK:2.8 μM |
| In vitro | Vero cells were treated with increasing concentrations of R 59-022 and exposed for 4 hours to MLV pseudotypes encoding LacZ and bearing EBOV GP or VSV-G in the presence of the drug. R 59-022 blocked an entry step specific to EBOV GP. Vero cells were treated with increasing concentrations of R 59-022 and exposed to VLPs bearing EBOV GP or VSV G in the presence of the drug for 3 h. By CCF2-AM staining and flow cytometry analysis, R 59-022 dose-dependent decrease in entry by the VLPs harboring the EBOV GP , IC50: ~2 µM. [5] |
| Synonyms | DKGI-I, Diacylglycerol kinase inhibitor I |
| Molecular Weight | 459.58 |
| Formula | C27H26FN3OS |
| Cas No. | 93076-89-2 |
| Smiles | O=C1C(=C(N=C2SC=CN21)C)CCN3CCC(=C(C=4C=CC=CC4)C5=CC=C(F)C=C5)CC3 |
| Relative Density. | 1.26g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (108.79 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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