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MPXV p37 protein-IN-1

Catalog No. T214196 Copy Product Info
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MPXV p37 protein-IN-1 is a potent and orally effective inhibitor of the monkeypox virus (MPXV) p37 protein. It exhibits significant antiviral activity against MPXV, with an EC50 of 12.14 nM, and shows low cytotoxicity (CC50= 304.63 μM). In mice, MPXV p37 protein-IN-1 demonstrates low toxicity and good tolerability. This compound can be utilized for research into anti-monkeypox virus drugs.

MPXV p37 protein-IN-1

Copy Product Info
🥰Excellent
Catalog No. T214196

MPXV p37 protein-IN-1 is a potent and orally effective inhibitor of the monkeypox virus (MPXV) p37 protein. It exhibits significant antiviral activity against MPXV, with an EC50 of 12.14 nM, and shows low cytotoxicity (CC50= 304.63 μM). In mice, MPXV p37 protein-IN-1 demonstrates low toxicity and good tolerability. This compound can be utilized for research into anti-monkeypox virus drugs.

MPXV p37 protein-IN-1
Cas No. 3096845-40-5
Pack SizePriceUSA StockGlobal StockQuantity
10 mgInquiry10-14 weeks10-14 weeks
50 mgInquiry10-14 weeks10-14 weeks
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
MPXV p37 protein-IN-1 is a potent and orally effective inhibitor of the monkeypox virus (MPXV) p37 protein. It exhibits significant antiviral activity against MPXV, with an EC50 of 12.14 nM, and shows low cytotoxicity (CC50= 304.63 μM). In mice, MPXV p37 protein-IN-1 demonstrates low toxicity and good tolerability. This compound can be utilized for research into anti-monkeypox virus drugs.
Targets&IC50
MPXV:12.14 nM (EC50)
In vitro
MPXV p37 protein-IN-1 (compound C12) exhibits potent anti-MPXV virus activity in Vero cells at a concentration of 1-10 μM over 48 hours. It forms essential hydrogen bonds with residues TYR258 and SER292, which may enhance its binding affinity and antiviral efficacy.
In vivo
Compound C12, also known as MPXV p37 protein-IN-1, is well-tolerated in CD-1 mice at a single oral dose of 2000 mg/kg. Additionally, a daily oral dose of 100 mg/kg administered over 14 consecutive days is also well-tolerated in the same mouse model.
Chemical Properties
Molecular Weight375.39
FormulaC18H15F2N3O2S
Cas No.3096845-40-5
SmilesO=C1[C@@]2([C@]3([C@]4([C@](C4)([C@@]([C@@]2(C(=O)N1NC(NC5=CC(F)=C(F)C=C5)=S)[H])(C=C3)[H])[H])[H])[H])[H]
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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