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NSC 625987

Name: NSC 625987
Brand: TargetMol
SKU: T23092
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23092Cas No. 141992-47-4

Alias NSC-625987, NSC625987

NSC 625987 is a selective, high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. Its selectivity for CDK4 is >500-fold greater than for CDK2, making it suitable for studying p16-associated tumors.

NSC 625987

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Purity: 99.01%

Catalog No. T23092Alias NSC-625987, NSC625987Cas No. 141992-47-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$61	-	In Stock
5 mg	$147	-	In Stock
10 mg	$239	-	In Stock
25 mg	$413	-	In Stock
50 mg	$662	-	In Stock
100 mg	$993	-	In Stock
1 mL x 10 mM (in DMSO)	$162	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.01%

Appearance:Solid

Color:Brown

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	NSC 625987 is a selective, high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. Its selectivity for CDK4 is >500-fold greater than for CDK2, making it suitable for studying p16-associated tumors.
Targets&IC50	CDK4/CyclinD1:0.2 μM
Synonyms	NSC-625987, NSC625987

Chemical Properties

Molecular Weight	271.33
Formula	C₁₅H₁₃NO₂S
Cas No.	141992-47-4
Smiles	S=C1C=2C=CC=CC2NC=3C(OC)=CC=C(OC)C13
Relative Density.	1.32g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: <1 mg/mL

DMSO: 80 mg/mL (294.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (3.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6855 mL	18.4277 mL	36.8555 mL	184.2774 mL
5 mM	0.7371 mL	3.6855 mL	7.3711 mL	36.8555 mL
10 mM	0.3686 mL	1.8428 mL	3.6855 mL	18.4277 mL
20 mM	0.1843 mL	0.9214 mL	1.8428 mL	9.2139 mL
50 mM	0.0737 mL	0.3686 mL	0.7371 mL	3.6855 mL
100 mM	0.0369 mL	0.1843 mL	0.3686 mL	1.8428 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc