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Azido-PEG4-NHS-ester

Name: Azido-PEG4-NHS-ester
Brand: TargetMol
SKU: T14451
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Azido-PEG4-NHS-ester is a PEG-based linker molecule that can be used as a linker in PROTAC construction. It contains an azide group that participates in click chemistry reactions, including copper-catalyzed azide–alkyne cycloaddition (CuAAC) with alkynes, as well as strain-promoted azide–alkyne cycloaddition (SPAAC) with DBCO or BCN groups, thereby enabling molecular conjugation.

Cas No. 1807534-82-2

Pack Size	Price	USA Stock	Global Stock	Quantity
5 mg	$40	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Appearance:Liquid

Color:Transparent

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COA

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	374.35
Formula	C₁₄H₂₂N₄O₈
Cas No.	1807534-82-2
Smiles	[N-]=[N+]=NCCOCCOCCOCCOCC(=O)ON1C(=O)CCC1=O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (213.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6713 mL	13.3565 mL	26.7130 mL	133.5648 mL
5 mM	0.5343 mL	2.6713 mL	5.3426 mL	26.7130 mL
10 mM	0.2671 mL	1.3356 mL	2.6713 mL	13.3565 mL
20 mM	0.1336 mL	0.6678 mL	1.3356 mL	6.6782 mL
50 mM	0.0534 mL	0.2671 mL	0.5343 mL	2.6713 mL
100 mM	0.0267 mL	0.1336 mL	0.2671 mL	1.3356 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc