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PNU-105368

Name: PNU-105368
Brand: TargetMol
SKU: T19647
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19647Cas No. 168828-90-8

Alias PNU105368

PNU-105368 is a bioactive chemical substance that can be used for related research in the field of life sciences.

PNU-105368

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Purity: 99.87%

Catalog No. T19647Alias PNU105368Cas No. 168828-90-8

PNU-105368 is a bioactive chemical substance that can be used for related research in the field of life sciences.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

PNU-105368 AI Summary

PNU-105368 demonstrates antibacterial activity primarily against gram-negative Escherichia coli strains and methicillin-susceptible Staphylococcus aureus ATCC 29213. However, it shows resistance against wild type E. coli MG1655, membrane permeabilized mutant, and AcrAB-TolC efflux pump deletion mutant, with a minimum inhibitory concentration (MIC) greater than 256.0 ug/mL, and against Staphylococcus aureus with an MIC greater than 64.0 ug/mL. Additionally, it has been tested against other bacterial strains including Salmonella enterica and Enterococcus faecalis, with MIC values greater than 128.0 ug/mL, indicating limited antibacterial activity against these species at the tested concentrations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PNU-105368 is a bioactive chemical substance that can be used for related research in the field of life sciences.
Synonyms	PNU105368

Chemical Properties

Molecular Weight	295.31
Formula	C₁₄H₁₈FN₃O₃
Cas No.	168828-90-8
Smiles	NC[C@H]1CN(C(=O)O1)c1ccc(N2CCOCC2)c(F)c1
Relative Density.	1.32 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (186.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3863 mL	16.9314 mL	33.8627 mL	169.3136 mL
5 mM	0.6773 mL	3.3863 mL	6.7725 mL	33.8627 mL
10 mM	0.3386 mL	1.6931 mL	3.3863 mL	16.9314 mL
20 mM	0.1693 mL	0.8466 mL	1.6931 mL	8.4657 mL
50 mM	0.0677 mL	0.3386 mL	0.6773 mL	3.3863 mL
100 mM	0.0339 mL	0.1693 mL	0.3386 mL	1.6931 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc