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L-778123 hydrochloride

Name: L-778123 hydrochloride
Brand: TargetMol
SKU: T3182
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3182Cas No. 253863-00-2

Alias L 778123

The L-778123 hydrochloride is an inhibitor of FPTase (IC50: 2 nM) and GGPTase-I (IC50: 98 nM) in enzyme inhibition determination.

L-778123 hydrochloride

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Purity: 98.51%

Catalog No. T3182Alias L 778123Cas No. 253863-00-2

The L-778123 hydrochloride is an inhibitor of FPTase (IC50: 2 nM) and GGPTase-I (IC50: 98 nM) in enzyme inhibition determination.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$38	In Stock	In Stock
5 mg	$61	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$159	In Stock	In Stock
50 mg	$262	In Stock	In Stock
100 mg	$442	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$63	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.51%

Color:Yellow

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COA LCMS HPLC HNMR

Product Introduction

L-778123 hydrochloride AI Summary

L-778123 hydrochloride exhibits significant antiviral activity, specifically against SARS-CoV-2, by inhibiting the virus-induced cytotoxicity in Caco-2 and VERO-6 cells at a concentration of 10 µM after 48 hours. The inhibition rates in these assays were 0.62% and -0.09%, respectively. Additionally, L-778123 hydrochloride shows an inhibition percentage of 16.87% on the SARS-CoV-2 3CL-Pro protease at a concentration of 20 µM, indicating its potential to inhibit viral replication. Beyond its antiviral properties, L-778123 hydrochloride acts as an inhibitor of human recombinant farnesyltransferase and Geranylgeranyl transferase-1 in mouse PBMC, with IC50 values of 2.0 nM and 98.0 nM, respectively. It also shows cytotoxic activity against human HepG2 cells, with an IC50 value of 1100 nM as determined by the CellTiter-Glo luminescent cell viability assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	The L-778123 hydrochloride is an inhibitor of FPTase (IC50: 2 nM) and GGPTase-I (IC50: 98 nM) in enzyme inhibition determination.
Targets&IC50	FPTase:2 nM, GGTase I:98 nM
Synonyms	L 778123

Chemical Properties

Molecular Weight	442.34
Formula	C₂₂H₂₁Cl₂N₅O
Cas No.	253863-00-2
Smiles	Cl.Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1=O
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (452.14 mM), Sonication is recommended.

In Vivo Formulation

PBS: 100 mg/mL (226.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2607 mL	11.3035 mL	22.6070 mL	113.0352 mL
5 mM	0.4521 mL	2.2607 mL	4.5214 mL	22.6070 mL
10 mM	0.2261 mL	1.1304 mL	2.2607 mL	11.3035 mL
20 mM	0.1130 mL	0.5652 mL	1.1304 mL	5.6518 mL
50 mM	0.0452 mL	0.2261 mL	0.4521 mL	2.2607 mL
100 mM	0.0226 mL	0.1130 mL	0.2261 mL	1.1304 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc