Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FTY720 (S)-Phosphate, an S1P receptor 1 (S1PR1) agonist, is utilized in studying acute inflammatory diseases, including acute lung injury.
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Description | FTY720 (S)-Phosphate, an S1P receptor 1 (S1PR1) agonist, is utilized in studying acute inflammatory diseases, including acute lung injury. |
In vitro | FTY720 (S)-Phosphate acts as an S1PR1 agonist, sustaining its protein expression and reinforcing the endothelial cell barrier in human pulmonary arteries through S1PR1 without promoting its ubiquitination. Moreover, at concentrations ranging from 0.01 to 50 μM, FTY720 (S)-Phosphate diminishes β-arrestin association with S1PR1 [1]. |
In vivo | FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) maintains S1PR1 expression in the lungs of mice, offers protection against bleomycin-induced acute lung injury (ALI), and reduces leukocyte infiltration in the lung tissues of mice injured by bleomycin [1]. |
Molecular Weight | 385.48 |
Formula | C20H36NO4P |
CAS No. | 1142015-10-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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(S)-FTY720-phosphonate 1142015-10-8 GPCR/G Protein LPL Receptor inhibitor inhibit