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Org-12962

Name: Org-12962
Brand: TargetMol
SKU: T16401
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16401Cas No. 132834-56-1

Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2A and 5-HT2B receptors (pEC50s: 6.38 and 6.28, respectively).

Org-12962

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Purity: 98.34%

Catalog No. T16401Cas No. 132834-56-1

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	-	In Stock
10 mg	$56	-	In Stock
25 mg	$83	-	In Stock
50 mg	$113	-	In Stock
100 mg	$162	-	In Stock
1 mL x 10 mM (in DMSO)	$44	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.34%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2A and 5-HT2B receptors (pEC50s: 6.38 and 6.28, respectively).
Targets&IC50	5-HT2B receptor:6.28 （pEC50）, 5-HT2A receptor:6.38 （pEC50）, 5-HT2C receptor:7.01 （pEC50）
In vivo	Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%). Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) obviously enhances the postinjection frequency thresholds for self-interruption (F3.71=11.40) [1].

Chemical Properties

Molecular Weight	265.66
Formula	C₁₀H₁₁ClF₃N₃
Cas No.	132834-56-1
Smiles	FC(F)(F)C1=CC=C(N=C1Cl)N1CCNCC1
Relative Density.	1.352 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (846.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (18.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7642 mL	18.8210 mL	37.6421 mL	188.2105 mL
5 mM	0.7528 mL	3.7642 mL	7.5284 mL	37.6421 mL
10 mM	0.3764 mL	1.8821 mL	3.7642 mL	18.8210 mL
20 mM	0.1882 mL	0.9411 mL	1.8821 mL	9.4105 mL
50 mM	0.0753 mL	0.3764 mL	0.7528 mL	3.7642 mL
100 mM	0.0376 mL	0.1882 mL	0.3764 mL	1.8821 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc