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Org-12962

🥰Excellent
Catalog No. T16401Cas No. 132834-56-1

Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2A and 5-HT2B receptors (pEC50s: 6.38 and 6.28, respectively).

Org-12962
Other Forms of Org-12962:
Org-12962 hydrochlorideT23110210821-63-9
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Org-12962

🥰Excellent
Purity: 98.34%
Catalog No. T16401Cas No. 132834-56-1
Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2A and 5-HT2B receptors (pEC50s: 6.38 and 6.28, respectively).
Pack SizePriceAvailabilityQuantity
5 mg$40In Stock
10 mg$56In Stock
25 mg$83In Stock
50 mg$113In Stock
100 mg$162In Stock
1 mL x 10 mM (in DMSO)$44In Stock
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Purity:98.34%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2A and 5-HT2B receptors (pEC50s: 6.38 and 6.28, respectively).
Targets&IC50
5-HT2C receptor:7.01 （pEC50）, 5-HT2B receptor:6.28 （pEC50）, 5-HT2A receptor:6.38 （pEC50）
In vivo
Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%). Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) obviously enhances the postinjection frequency thresholds for self-interruption (F3.71=11.40) [1].
Chemical Properties
Molecular Weight265.66
FormulaC10H11ClF3N3
Cas No.132834-56-1
SmilesFC(F)(F)C1=CC=C(N=C1Cl)N1CCNCC1
Relative Density.1.352 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 225 mg/mL (846.9 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7642 mL18.8210 mL37.6421 mL188.2105 mL
5 mM0.7528 mL3.7642 mL7.5284 mL37.6421 mL
10 mM0.3764 mL1.8821 mL3.7642 mL18.8210 mL
20 mM0.1882 mL0.9411 mL1.8821 mL9.4105 mL
50 mM0.0753 mL0.3764 mL0.7528 mL3.7642 mL
100 mM0.0376 mL0.1882 mL0.3764 mL1.8821 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Keywords

Org-12962Org12962Org 129625HTReceptor5-HT2C Receptor5-HT2C5-HT2B Receptor5-HT2B5-HT2A Receptor5-HT2A5HT Receptor
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