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Anti-NR1H4 Polyclonal Antibody
(Synonyms: RIP14, nuclear receptor subfamily 1, group H, member 4, HRR-1, HRR1, FXR, BAR) Copy Product Info
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Synonyms: RIP14, nuclear receptor subfamily 1, group H, member 4, HRR-1, HRR1, FXR, BAR
Catalog No. TMAB-01264 Copy Product Info
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Anti-NR1H4 Polyclonal Antibody is a Rabbit antibody targeting NR1H4. Anti-NR1H4 Polyclonal Antibody can be used in FCM, ICC/IF, WB.
Anti-NR1H4 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-NR1H4 Polyclonal Antibody is a Rabbit antibody targeting NR1H4. Anti-NR1H4 Polyclonal Antibody can be used in FCM, ICC/IF, WB. |
| Synonyms | RIP14, nuclear receptor subfamily 1, group H, member 4, HRR-1, HRR1, FXR, BAR |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat,Dog,Pig,Cow,Horse,Sheep) |
| Application | |
| Recommended Dose | FCM=2 μg/Test; ICC/IF=1:50-200; WB=1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, and several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed “orphan receptors” because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid. |
| Immunogen | KLH conjugated synthetic peptide: human FXR/Bile Acid Receptor NR1H4 |
| Antigen Species | Human |
| Gene Name | NR1H4 |
| Gene ID | |
| Protein Name | Bile acid receptor |
| Uniprot ID | |
| Biology Area | Orphan Nuclear Receptors,Energy Metabolism,Energy Metabolism,Lipid metabolism |
| Function | Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus. |
| Molecular Weight | Theoretical: 56 kDa. Actual: 50 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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