Shopping Cart

Your shopping cart is currently empty

VZ185

Name: VZ185
Brand: TargetMol
SKU: T17249
Price: 136 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T17249Cas No. 2306193-61-1

Alias VZ-185, VZ 185

VZ185 is a potent, fast-acting, and selective von Hippel–Lindau–based dual degrader probe targeting BRD9 and BRD7 with DC50 values of 4.5 nM and 1.8 nM, respectively. VZ185 displays marked cytotoxicity in EOL-1 and A-402 cell lines with EC50 values of 3 nM and 40 nM, enabling advanced studies of chromatin remodeling, targeted protein degradation, and cancer cell dependency on SWI/SNF complex components.

VZ185

Copy Product Info

😃Good

Purity: 99.98%

Catalog No. T17249Alias VZ-185, VZ 185Cas No. 2306193-61-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$136	-	In Stock
5 mg	$289	-	In Stock
10 mg	$396	-	In Stock
25 mg	$787	-	In Stock
50 mg	$1,190	-	In Stock
1 mL x 10 mM (in DMSO)	$533	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.98%

Appearance:Solid

Color:White

Resource Download

Product Introduction

Bioactivity

Description	VZ185 is a potent, fast-acting, and selective von Hippel–Lindau–based dual degrader probe targeting BRD9 and BRD7 with DC50 values of 4.5 nM and 1.8 nM, respectively. VZ185 displays marked cytotoxicity in EOL-1 and A-402 cell lines with EC50 values of 3 nM and 40 nM, enabling advanced studies of chromatin remodeling, targeted protein degradation, and cancer cell dependency on SWI/SNF complex components.
Targets&IC50	BRD9:1.8 nM(DC), BRD7:4.5 nM(DC)
In vitro	In biochemical assays, VZ185 functioned as a dual degrader recruiting VHL E3 ligase, exhibiting DC50 values of 1.8 nM for BRD9 and 4.5 nM for BRD7. In cellular assays utilizing human cancer cell lines EOL-1 and A-204, the compound mediated BRD9 degradation with DC50 values ranging from 2 to 8 nM while maintaining stability in plasma and microsomes [1].
Synonyms	VZ-185, VZ 185

Chemical Properties

Molecular Weight	995.21
Formula	C₅₃H₆₇FN₈O₈S
Cas No.	2306193-61-1
Smiles	CN1C=C(C=2C(C1=O)=CN=CC2)C3=CC(OC)=C(CN4CCN(CCCCCOC5=C(CNC(=O)[C@H]6N(C([C@@H](NC(=O)C7(F)CC7)C(C)(C)C)=O)C[C@H](O)C6)C=CC(=C5)C=8SC=NC8C)CC4)C(OC)=C3
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (160.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0048 mL	5.0241 mL	10.0481 mL	50.2407 mL
5 mM	0.2010 mL	1.0048 mL	2.0096 mL	10.0481 mL
10 mM	0.1005 mL	0.5024 mL	1.0048 mL	5.0241 mL
20 mM	0.0502 mL	0.2512 mL	0.5024 mL	2.5120 mL
50 mM	0.0201 mL	0.1005 mL	0.2010 mL	1.0048 mL
100 mM	0.0100 mL	0.0502 mL	0.1005 mL	0.5024 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc