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Migoprotafib

Name: Migoprotafib
Brand: TargetMol
SKU: T62798
Rating: 4.5 (1 reviews)

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Catalog No. T62798Cas No. 2377352-49-1

Alias RO-7517834, RLY-1971, RG 6433, GDC-1971, GDC1971

Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for the study of advanced solid tumours.

Migoprotafib

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Catalog No. T62798Alias RO-7517834, RLY-1971, RG 6433, GDC-1971, GDC1971Cas No. 2377352-49-1

Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for the study of advanced solid tumours.

Pack Size	Price	Availability
1 mg	$146	6-8 weeks
5 mg	$363	6-8 weeks
10 mg	$582	6-8 weeks
25 mg	$1,170	6-8 weeks
50 mg	$1,870	6-8 weeks
100 mg	$2,970	6-8 weeks
1 mL x 10 mM (in DMSO)	$392	6-8 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for the study of advanced solid tumours.
In vitro	Migoprotafib is a selective SHP2 inhibitor that demonstrates potent antiproliferative activity in various tumor cell lines (e.g., NCI-H358, KYSE520, and LoVo). In vitro, Migoprotafib (0.001–10 μM, 2–6 days) alone or in combination with KRAS G12C inhibitors (e.g., GDC-6036) significantly suppressed pERK levels and induced cell cycle arrest, indicating effective MAPK pathway inhibition[1].
In vivo	In mouse xenograft models, Migoprotafib (30–60 mg/kg, oral gavage, once daily) showed strong antitumor efficacy, particularly in combination with KRAS G12C inhibitors (e.g., GDC-6036), resulting in complete or substantial tumor regression (treatment up to 21 days)[1].
Alias	RO-7517834, RLY-1971, RG 6433, GDC-1971, GDC1971

Chemical Properties

Molecular Weight	454.53
Formula	C₂₅H₂₆N₈O
Cas No.	2377352-49-1
Smiles	N[C@H]1C2(OC=3C1=CC=CC3)CCN(CC2)C=4N=C5C(=NC4)C(=NN5)N6C=7C(CCC6)=NC=CC7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (176.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2001 mL	11.0004 mL	22.0007 mL	110.0037 mL
5 mM	0.4400 mL	2.2001 mL	4.4001 mL	22.0007 mL
10 mM	0.2200 mL	1.1000 mL	2.2001 mL	11.0004 mL
20 mM	0.1100 mL	0.5500 mL	1.1000 mL	5.5002 mL
50 mM	0.0440 mL	0.2200 mL	0.4400 mL	2.2001 mL
100 mM	0.0220 mL	0.1100 mL	0.2200 mL	1.1000 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Migoprotafib

Migoprotafib

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