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Migoprotafib

Name: Migoprotafib
Brand: TargetMol
SKU: T62798
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T62798Cas No. 2377352-49-1

Alias RO-7517834, RLY-1971, RG 6433, GDC-1971, GDC1971

Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for the study of advanced solid tumours.

Migoprotafib

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Purity: 98.31%

Catalog No. T62798Alias RO-7517834, RLY-1971, RG 6433, GDC-1971, GDC1971Cas No. 2377352-49-1

Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for the study of advanced solid tumours.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$139	-	In Stock
5 mg	$347	-	In Stock
10 mg	$553	-	In Stock
25 mg	$1,090	-	In Stock
50 mg	$1,780	-	In Stock
100 mg	$2,880	-	In Stock
1 mL x 10 mM (in DMSO)	$379	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.31%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for the study of advanced solid tumours.
In vitro	Migoprotafib is a selective SHP2 inhibitor that demonstrates potent antiproliferative activity in various tumor cell lines (e.g., NCI-H358, KYSE520, and LoVo). In vitro, Migoprotafib (0.001–10 μM, 2–6 days) alone or in combination with KRAS G12C inhibitors (e.g., GDC-6036) significantly suppressed pERK levels and induced cell cycle arrest, indicating effective MAPK pathway inhibition[1].
In vivo	In mouse xenograft models, Migoprotafib (30–60 mg/kg, oral gavage, once daily) showed strong antitumor efficacy, particularly in combination with KRAS G12C inhibitors (e.g., GDC-6036), resulting in complete or substantial tumor regression (treatment up to 21 days)[1].
Synonyms	RO-7517834, RLY-1971, RG 6433, GDC-1971, GDC1971

Chemical Properties

Molecular Weight	454.53
Formula	C₂₅H₂₆N₈O
Cas No.	2377352-49-1
Smiles	N[C@H]1C2(OC=3C1=CC=CC3)CCN(CC2)C=4N=C5C(=NC4)C(=NN5)N6C=7C(CCC6)=NC=CC7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (176.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2001 mL	11.0004 mL	22.0007 mL	110.0037 mL
5 mM	0.4400 mL	2.2001 mL	4.4001 mL	22.0007 mL
10 mM	0.2200 mL	1.1000 mL	2.2001 mL	11.0004 mL
20 mM	0.1100 mL	0.5500 mL	1.1000 mL	5.5002 mL
50 mM	0.0440 mL	0.2200 mL	0.4400 mL	2.2001 mL
100 mM	0.0220 mL	0.1100 mL	0.2200 mL	1.1000 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Migoprotafib

Migoprotafib

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