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Cystathionine-γ-lyase-IN-1

Name: Cystathionine-γ-lyase-IN-1
Brand: TargetMol
SKU: T64354
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T64354Cas No. 2165706-30-7

Alias SHIP-2a

Cystathionine-γ-lyase-IN-1 (SHIP-2a) is a selective inhibitor of cystathionine γ-lyase (CSE) enzyme (IC50= 6.3 μM).

Cystathionine-γ-lyase-IN-1

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Purity: 98.55%

Catalog No. T64354Alias SHIP-2aCas No. 2165706-30-7

Cystathionine-γ-lyase-IN-1 (SHIP-2a) is a selective inhibitor of cystathionine γ-lyase (CSE) enzyme (IC50= 6.3 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$34	In Stock	In Stock
5 mg	$54	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$188	In Stock	In Stock
50 mg	$302	In Stock	In Stock
100 mg	$472	In Stock	In Stock
200 mg	$691	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.55%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Cystathionine-γ-lyase-IN-1 (SHIP-2a) is a selective inhibitor of cystathionine γ-lyase (CSE) enzyme (IC50= 6.3 μM).
In vitro	Cystathionine-γ-lyase-IN-1 (100 μM) completely abrogates L-cysteine-induced vasorelaxation. Cystathionine-γ-lyase-IN-1 (100 μM; 30 minutes) significantly inhibits the increased H2S production stimulated by L-cysteine in mouse aorta homogenates[1].
Synonyms	SHIP-2a

Chemical Properties

Molecular Weight	184.22
Formula	C₇H₈N₂O₂S
Cas No.	2165706-30-7
Smiles	O=C(NCC#C)[C@@H]1CSC(=O)N1
Relative Density.	1.339 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (298.56 mM), Sonication is recommended.

Ethanol: 8.1 mg/mL (43.97 mM), Sonication and heating are recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4283 mL	27.1415 mL	54.2829 mL	271.4146 mL
5 mM	1.0857 mL	5.4283 mL	10.8566 mL	54.2829 mL
10 mM	0.5428 mL	2.7141 mL	5.4283 mL	27.1415 mL
20 mM	0.2714 mL	1.3571 mL	2.7141 mL	13.5707 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.1086 mL	0.5428 mL	1.0857 mL	5.4283 mL
100 mM	0.0543 mL	0.2714 mL	0.5428 mL	2.7141 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc