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BM-531
🥰Excellent
Catalog No. TXB-00085Cas No. 284464-46-6
Alias BM531, BM 531
BM-531 is a thromboxane A2 receptor (TXA2R) antagonist (IC₅₀ = 7.8 nM) and thromboxane synthase inhibitor exhibiting antiplatelet activity. It inhibits arachidonic acid-induced platelet aggregation and suppresses the second wave of ADP-induced aggregation.
BM-531
🥰Excellent
Purity: 97.46%
Catalog No. TXB-00085Alias BM531, BM 531Cas No. 284464-46-6
BM-531 is a thromboxane A2 receptor (TXA2R) antagonist (IC₅₀ = 7.8 nM) and thromboxane synthase inhibitor exhibiting antiplatelet activity. It inhibits arachidonic acid-induced platelet aggregation and suppresses the second wave of ADP-induced aggregation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock | |
| 5 mg | $483 | In Stock | |
| 10 mg | $691 | In Stock | |
| 25 mg | $1,080 | In Stock | |
| 50 mg | $1,490 | In Stock |
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Purity:97.46%
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Product Introduction
Bioactivity
Chemical Properties
| Description | BM-531 is a thromboxane A2 receptor (TXA2R) antagonist (IC₅₀ = 7.8 nM) and thromboxane synthase inhibitor exhibiting antiplatelet activity. It inhibits arachidonic acid-induced platelet aggregation and suppresses the second wave of ADP-induced aggregation. |
| Targets&IC50 | TXA2:7.8 nM |
| In vitro | BM-531 (0.0001-10 μM) exhibits high affinity for the thromboxane A₂ (TXA₂) receptor in homo sapiens platelets (IC₅₀ = 0.0078 μM, determined by competitive displacement of [³H]SQ-29548) [1]. BM-531 demonstrates anti-aggregatory effects in homo sapiens platelet-rich plasma (PRP), inhibiting arachidonic acid-induced platelet aggregation (ED₁₀₀ = 0.125 μM) and U-46619-induced platelet aggregation (ED₅₀ = 0.482 μM) [1]. BM-531 (10 μM) inhibits high K⁺-induced contraction in porcine uterine smooth muscle after 1 hour of treatment [2]. |
| Synonyms | BM531, BM 531 |
| Molecular Weight | 398.48 |
| Formula | C17H26N4O5S |
| Cas No. | 284464-46-6 |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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