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Anti-IREB2 Polyclonal Antibody

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Catalog No. TMAB-00984
Alias OTTHUMP00000185022, IRP2AD, IRP-2, irp2, IRP2, Iron-responsive element-binding protein 2, iron regulatory protein 2, IRE-BP 2, IREB2, IREB 2, IRE BP2, FLJ23381, ACO3

Anti-IREB2 Polyclonal Antibody is a Rabbit antibody targeting IREB2. Anti-IREB2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-IREB2 Polyclonal Antibody

Anti-IREB2 Polyclonal Antibody

😃Good
Catalog No. TMAB-00984Alias OTTHUMP00000185022, IRP2AD, IRP-2, irp2, IRP2, Iron-responsive element-binding protein 2, iron regulatory protein 2, IRE-BP 2, IREB2, IREB 2, IRE BP2, FLJ23381, ACO3
Anti-IREB2 Polyclonal Antibody is a Rabbit antibody targeting IREB2. Anti-IREB2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Pack SizePriceAvailabilityQuantity
50 μL$2217-10 days
100 μL$3727-10 days
200 μL$5287-10 days
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Product Introduction

Bioactivity
Description
Anti-IREB2 Polyclonal Antibody is a Rabbit antibody targeting IREB2. Anti-IREB2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
AliasOTTHUMP00000185022, IRP2AD, IRP-2, irp2, IRP2, Iron-responsive element-binding protein 2, iron regulatory protein 2, IRE-BP 2, IREB2, IREB 2, IRE BP2, FLJ23381, ACO3
Ig Type
IgG
Reactivity
Human,Mouse (predicted:Rat,Chicken,Dog,Rabbit)
Verified Activity
1. Paraformaldehyde-fixed, paraffin embedded (human kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (IREB2) Polyclonal Antibody, Unconjugated (TMAB-00984) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
2. Paraformaldehyde-fixed, paraffin embedded (Human duodenum); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (IREB2) Polyclonal Antibody, Unconjugated (TMAB-00984) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
3. Paraformaldehyde-fixed, paraffin embedded (mouse kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (IREB2) Polyclonal Antibody, Unconjugated (TMAB-00984) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
Application
IHC-P,IHC-Fr,IF
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm.
ConstructionHybridoma Polyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Research BackgroundIron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins: IRP-1 and -2 (iron regulatory protein-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE-BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human IREB2
Antigen Species
Human
Gene ID
Uniprot ID
Biology Area
Blood,Hypoxia-Regulated,RNA Processing,Vitamins / minerals,Energy Metabolism,Nucleotide metabolism,Hypoxia,Energy Metabolism,Vitamins / Minerals
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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