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Vodobatinib

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Catalog No. T8882Cas No. 1388803-90-4
Alias K-0706

Vodobatinib (K-0706) is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity.

Vodobatinib

Vodobatinib

😃Good
Purity: 99.55%
Catalog No. T8882Alias K-0706Cas No. 1388803-90-4
Vodobatinib (K-0706) is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$31In StockIn Stock
5 mg$72In StockIn Stock
10 mg$118In StockIn Stock
25 mg$223In StockIn Stock
50 mg$358In StockIn Stock
100 mg$556In StockIn Stock
500 mg$1,343-In Stock
1 mL x 10 mM (in DMSO)$79In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.55%
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Product Introduction

Bioactivity
Description
Vodobatinib (K-0706) is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity.
Targets&IC50
BCR-ABL1:7 nM (IC50)
SynonymsK-0706
Chemical Properties
Molecular Weight453.92
FormulaC27H20ClN3O2
Cas No.1388803-90-4
SmilesCc1ccc(cc1C#Cc1cnc2ccccc2c1)C(=O)NNC(=O)c1c(C)cccc1Cl
Relative Density.1.35 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 25 mg/mL (55.08 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2 mg/mL (4.41 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2030 mL11.0152 mL22.0303 mL110.1516 mL
5 mM0.4406 mL2.2030 mL4.4061 mL22.0303 mL
10 mM0.2203 mL1.1015 mL2.2030 mL11.0152 mL
20 mM0.1102 mL0.5508 mL1.1015 mL5.5076 mL
50 mM0.0441 mL0.2203 mL0.4406 mL2.2030 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VodobatinibTKImyeloidleukemiaK0706K 0706InhibitorinhibitchronicBcr-Abl1BCR-ABL1Bcr-AblBcrAbl
Related Tags: buy Vodobatinib | purchase Vodobatinib | Vodobatinib cost | order Vodobatinib | Vodobatinib chemical structure | Vodobatinib formula | Vodobatinib molecular weight
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