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Vodobatinib

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Catalog No. T8882Cas No. 1388803-90-4

Alias K-0706

Vodobatinib (K-0706) is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity.

Vodobatinib

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Purity: 99.55%

Catalog No. T8882Alias K-0706Cas No. 1388803-90-4

Vodobatinib (K-0706) is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$118	In Stock	In Stock
25 mg	$223	In Stock	In Stock
50 mg	$358	In Stock	In Stock
100 mg	$556	In Stock	In Stock
500 mg	$1,343	-	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.55%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Vodobatinib AI Summary

Vodobatinib demonstrates a brain-to-plasma drug level ratio (BPR) of 0.4 in C57BL6 mice when administered at a dosage of 30 mg/kg orally, suggesting moderate brain distribution compared to plasma after 1 hour, as analyzed by LC/MS. It is a potent inhibitor of wild type BCR-ABL phosphorylation in mouse BaF3 cells, with an IC50 of 0.9 nM, and also shows inhibitory activity against various BCR-ABL mutants (L248R, Y253H, E255V, T315I) with IC50 values ranging from 154.0 nM to 1967.0 nM. The compound exhibits good tissue distribution, evidenced by a plasma concentration of 4798.0 ng/ml and a brain concentration of 1901.0 ng/g at the same dose and time point..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Vodobatinib (K-0706) is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity.
Targets&IC50	BCR-ABL1:7 nM (IC50)
Synonyms	K-0706

Chemical Properties

Molecular Weight	453.92
Formula	C₂₇H₂₀ClN₃O₂
Cas No.	1388803-90-4
Smiles	Cc1ccc(cc1C#Cc1cnc2ccccc2c1)C(=O)NNC(=O)c1c(C)cccc1Cl
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (275.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (4.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2030 mL	11.0152 mL	22.0303 mL	110.1516 mL
5 mM	0.4406 mL	2.2030 mL	4.4061 mL	22.0303 mL
10 mM	0.2203 mL	1.1015 mL	2.2030 mL	11.0152 mL
20 mM	0.1102 mL	0.5508 mL	1.1015 mL	5.5076 mL
50 mM	0.0441 mL	0.2203 mL	0.4406 mL	2.2030 mL
100 mM	0.0220 mL	0.1102 mL	0.2203 mL	1.1015 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc