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Vodobatinib

Name: Vodobatinib
Brand: TargetMol
SKU: T8882
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8882Cas No. 1388803-90-4

Alias K-0706

Vodobatinib (K-0706) is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity.

Vodobatinib

🥰Excellent

Purity: 99.55%

Catalog No. T8882Alias K-0706Cas No. 1388803-90-4

Vodobatinib (K-0706) is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity.

Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$72	In Stock
10 mg	$118	In Stock
25 mg	$223	In Stock
50 mg	$358	In Stock
100 mg	$556	In Stock
500 mg	$1,343	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock

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Batch Information

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Purity:99.55%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Vodobatinib (K-0706) is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity.
Targets&IC50	BCR-ABL1:7 nM (IC50)
Synonyms	K-0706

Chemical Properties

Molecular Weight	453.92
Formula	C₂₇H₂₀ClN₃O₂
Cas No.	1388803-90-4
Smiles	Cc1ccc(cc1C#Cc1cnc2ccccc2c1)C(=O)NNC(=O)c1c(C)cccc1Cl
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (55.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2030 mL	11.0152 mL	22.0303 mL	110.1516 mL
5 mM	0.4406 mL	2.2030 mL	4.4061 mL	22.0303 mL
10 mM	0.2203 mL	1.1015 mL	2.2030 mL	11.0152 mL
20 mM	0.1102 mL	0.5508 mL	1.1015 mL	5.5076 mL
50 mM	0.0441 mL	0.2203 mL	0.4406 mL	2.2030 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc