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AMG-25

Name: AMG-25
Brand: TargetMol
SKU: T22256
Price: 499 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22256Cas No. 1003311-62-3

Alias c-Kit-IN-5-1

AMG-25 (c-Kit-IN-5-1) is a selective and potent c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used in the study of mast cell-associated fibrosis.

AMG-25

🥰Excellent

Purity: 98.16%

Catalog No. T22256Alias c-Kit-IN-5-1Cas No. 1003311-62-3

AMG-25 (c-Kit-IN-5-1) is a selective and potent c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used in the study of mast cell-associated fibrosis.

Pack Size	Price	Availability	Quantity
2 mg	$499	In Stock

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Batch Information

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Purity:98.16%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	AMG-25 (c-Kit-IN-5-1) is a selective and potent c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used in the study of mast cell-associated fibrosis.
Synonyms	c-Kit-IN-5-1

Chemical Properties

Molecular Weight	395.41
Formula	C₂₃H₁₇N₅O₂
Cas No.	1003311-62-3
Smiles	Cc1ccn(-c2ccc(cc2)-c2ncco2)c(=O)c1-c1ccc2nc(N)ncc2c1
Relative Density.	1.367 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (50.58 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5290 mL	12.6451 mL	25.2902 mL	126.4510 mL
5 mM	0.5058 mL	2.5290 mL	5.0580 mL	25.2902 mL
10 mM	0.2529 mL	1.2645 mL	2.5290 mL	12.6451 mL
20 mM	0.1265 mL	0.6323 mL	1.2645 mL	6.3226 mL
50 mM	0.0506 mL	0.2529 mL	0.5058 mL	2.5290 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc