Shopping Cart

Your shopping cart is currently empty

Lomibuvir

Name: Lomibuvir
Brand: TargetMol
SKU: T6729
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6729Cas No. 1026785-55-6

Alias VX-222, VCH-222

Lomibuvir (VCH-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC 50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo -initiated RNA synthesis [1].

Lomibuvir

🥰Excellent

Purity: 99.83%

Catalog No. T6729Alias VX-222, VCH-222Cas No. 1026785-55-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$37	In Stock	In Stock
5 mg	$85	In Stock	In Stock
10 mg	$139	In Stock	In Stock
25 mg	$268	In Stock	In Stock
50 mg	$428	In Stock	-
1 mL x 10 mM (in DMSO)	$94	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.83%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Lomibuvir (VCH-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC 50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo -initiated RNA synthesis [1].
Targets&IC50	HCV NS5B 1a:0.94-1.2 μM
In vitro	Lomibuvir (VX-222) is an effective non-nucleoside, allosteric inhibitor of the hepatitis C virus NS5B polymerase, exhibiting strong clinical efficacy. It demonstrates potent inhibition against the wild-type HCV 1b/Con1 replicon with an EC50 of 5.2 nM and against mutant replicons M423T, L419M, and I482L with EC50s of 79.8, 563.1, and 45.3 nM, respectively. Besides slightly hindering de novo initiation, Lomibuvir prominently impairs primer extension, illustrated by an IC50 of 31 nM for primer-extended RNA synthesis.
In vivo	In rats and dogs, Lomibuvir displays fine pharmacokinetic prole, including low total body clearance and excellent oral bioavailability (greater than 30%) and good ADME properties. Lomibuvir is biotransformed by several enzymes (CYP1A1, 2A6, 2B6, 2C8, CYP 3A4, UGT1A3) and is predicted to be actively transported in liver and excreted mainly intact in bile or as glucuronide adducts. [3]
Synonyms	VX-222, VCH-222

Chemical Properties

Molecular Weight	445.61
Formula	C₂₅H₃₅NO₄S
Cas No.	1026785-55-6
Smiles	CC1CCC(CC1)C(=O)N(C1CCC(O)CC1)c1cc(sc1C(O)=O)C#CC(C)(C)C
Relative Density.	1.21 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 82 mg/mL (184.02 mM), Sonication is recommended.

DMSO: 82 mg/mL (184.02 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2441 mL	11.2206 mL	22.4411 mL	112.2057 mL
5 mM	0.4488 mL	2.2441 mL	4.4882 mL	22.4411 mL
10 mM	0.2244 mL	1.1221 mL	2.2441 mL	11.2206 mL
20 mM	0.1122 mL	0.5610 mL	1.1221 mL	5.6103 mL
50 mM	0.0449 mL	0.2244 mL	0.4488 mL	2.2441 mL
100 mM	0.0224 mL	0.1122 mL	0.2244 mL	1.1221 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc